Hydrogenolytic transformations of 5a,11a-epoxyhexahydronaphthacene-5,6,11, 12-tetrones. Implications for the synthesis of 6- and 11-deoxyanthracyclinones

Peter N. Preston, Thomas Winwick, John O. Morley

Research output: Contribution to journalArticle

Abstract

Catalytic hydrogenation (H2, Pd-C) of the epoxide (5a) gives the dione derivative (6); an analogous procedure (5d)? (7) has been used in a sequence (5b)?(5c)?(5d)?(7)?(2d)?(2b) to give a valuable intermediate (2b) for the synthesis of 4,11-dideoxyanthracyclinones: implications for interconversions in the anthracyclinone series are described.

Original languageEnglish
Pages (from-to)307-308
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number5
Publication statusPublished - 1984

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