Hydrogenolytic transformations of 5a,11a-epoxyhexahydronaphthacene-5,6,11, 12-tetrones. Implications for the synthesis of 6- and 11-deoxyanthracyclinones

Peter N. Preston; Thomas Winwick; John O. Morley

Hydrogenolytic transformations of 5a,11a-epoxyhexahydronaphthacene-5,6,11, 12-tetrones. Implications for the synthesis of 6- and 11-deoxyanthracyclinones

Peter N. Preston, Thomas Winwick, John O. Morley

School of Engineering & Physical Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Catalytic hydrogenation (H₂, Pd-C) of the epoxide (5a) gives the dione derivative (6); an analogous procedure (5d)? (7) has been used in a sequence (5b)?(5c)?(5d)?(7)?(2d)?(2b) to give a valuable intermediate (2b) for the synthesis of 4,11-dideoxyanthracyclinones: implications for interconversions in the anthracyclinone series are described.

Original language	English
Pages (from-to)	307-308
Number of pages	2
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	5
Publication status	Published - 1984

Cite this

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title = "Hydrogenolytic transformations of 5a,11a-epoxyhexahydronaphthacene-5,6,11, 12-tetrones. Implications for the synthesis of 6- and 11-deoxyanthracyclinones",

abstract = "Catalytic hydrogenation (H2, Pd-C) of the epoxide (5a) gives the dione derivative (6); an analogous procedure (5d)? (7) has been used in a sequence (5b)?(5c)?(5d)?(7)?(2d)?(2b) to give a valuable intermediate (2b) for the synthesis of 4,11-dideoxyanthracyclinones: implications for interconversions in the anthracyclinone series are described.",

author = "Preston, \{Peter N.\} and Thomas Winwick and Morley, \{John O.\}",

year = "1984",

language = "English",

pages = "307--308",

journal = "Journal of the Chemical Society, Chemical Communications",

issn = "0022-4936",

publisher = "Chemical Society",

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T1 - Hydrogenolytic transformations of 5a,11a-epoxyhexahydronaphthacene-5,6,11, 12-tetrones. Implications for the synthesis of 6- and 11-deoxyanthracyclinones

AU - Preston, Peter N.

AU - Winwick, Thomas

AU - Morley, John O.

PY - 1984

Y1 - 1984

N2 - Catalytic hydrogenation (H2, Pd-C) of the epoxide (5a) gives the dione derivative (6); an analogous procedure (5d)? (7) has been used in a sequence (5b)?(5c)?(5d)?(7)?(2d)?(2b) to give a valuable intermediate (2b) for the synthesis of 4,11-dideoxyanthracyclinones: implications for interconversions in the anthracyclinone series are described.

AB - Catalytic hydrogenation (H2, Pd-C) of the epoxide (5a) gives the dione derivative (6); an analogous procedure (5d)? (7) has been used in a sequence (5b)?(5c)?(5d)?(7)?(2d)?(2b) to give a valuable intermediate (2b) for the synthesis of 4,11-dideoxyanthracyclinones: implications for interconversions in the anthracyclinone series are described.

UR - https://www.scopus.com/pages/publications/37049101273

M3 - Article

SN - 0022-4936

SP - 307

EP - 308

JO - Journal of the Chemical Society, Chemical Communications

JF - Journal of the Chemical Society, Chemical Communications

IS - 5

ER -

Hydrogenolytic transformations of 5a,11a-epoxyhexahydronaphthacene-5,6,11, 12-tetrones. Implications for the synthesis of 6- and 11-deoxyanthracyclinones

Abstract

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