Hydrogenolytic transformations of 5a,11a-epoxyhexahydronaphthacene-5,6,11, 12-tetrones. Implications for the synthesis of 6- and 11-deoxyanthracyclinones

Peter N. Preston; Thomas Winwick; John O. Morley

Hydrogenolytic transformations of 5a,11a-epoxyhexahydronaphthacene-5,6,11, 12-tetrones. Implications for the synthesis of 6- and 11-deoxyanthracyclinones

Peter N. Preston, Thomas Winwick, John O. Morley

School of Engineering & Physical Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Catalytic hydrogenation (H₂, Pd-C) of the epoxide (5a) gives the dione derivative (6); an analogous procedure (5d)? (7) has been used in a sequence (5b)?(5c)?(5d)?(7)?(2d)?(2b) to give a valuable intermediate (2b) for the synthesis of 4,11-dideoxyanthracyclinones: implications for interconversions in the anthracyclinone series are described.

Original language	English
Pages (from-to)	307-308
Number of pages	2
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	5
Publication status	Published - 1984

Cite this

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abstract = "Catalytic hydrogenation (H2, Pd-C) of the epoxide (5a) gives the dione derivative (6); an analogous procedure (5d)? (7) has been used in a sequence (5b)?(5c)?(5d)?(7)?(2d)?(2b) to give a valuable intermediate (2b) for the synthesis of 4,11-dideoxyanthracyclinones: implications for interconversions in the anthracyclinone series are described.",

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journal = "Journal of the Chemical Society, Chemical Communications",

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AU - Preston, Peter N.

AU - Winwick, Thomas

AU - Morley, John O.

PY - 1984

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N2 - Catalytic hydrogenation (H2, Pd-C) of the epoxide (5a) gives the dione derivative (6); an analogous procedure (5d)? (7) has been used in a sequence (5b)?(5c)?(5d)?(7)?(2d)?(2b) to give a valuable intermediate (2b) for the synthesis of 4,11-dideoxyanthracyclinones: implications for interconversions in the anthracyclinone series are described.

AB - Catalytic hydrogenation (H2, Pd-C) of the epoxide (5a) gives the dione derivative (6); an analogous procedure (5d)? (7) has been used in a sequence (5b)?(5c)?(5d)?(7)?(2d)?(2b) to give a valuable intermediate (2b) for the synthesis of 4,11-dideoxyanthracyclinones: implications for interconversions in the anthracyclinone series are described.

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M3 - Article

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ER -

Hydrogenolytic transformations of 5a,11a-epoxyhexahydronaphthacene-5,6,11, 12-tetrones. Implications for the synthesis of 6- and 11-deoxyanthracyclinones

Abstract

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