By building key structural features into hydrophilic drugs, they can be recognized by the PepT1 transporter system of the small intestine and rendered orally active. The model shown provides, for the first time, a 3D template for all known substrates of PepT1.
|Number of pages||3|
|Journal||Angewandte Chemie International Edition|
|Publication status||Published - 4 Feb 2000|
- Drug research
- Molecular modeling
- Molecular recognition
- Structure-activity relationships