How to make drugs orally active: A substrate template for peptide transporter PePT1

Patrick D. Bailey, C. A R Boyd, J. Ramsey Bronk, Ian D. Collier, David Meredith, Keith M. Morgan, Catherine S. Temple

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

By building key structural features into hydrophilic drugs, they can be recognized by the PepT1 transporter system of the small intestine and rendered orally active. The model shown provides, for the first time, a 3D template for all known substrates of PepT1.

Original languageEnglish
Pages (from-to)506-508
Number of pages3
JournalAngewandte Chemie International Edition
Volume39
Issue number3
Publication statusPublished - 4 Feb 2000

Keywords

  • Drug research
  • Molecular modeling
  • Molecular recognition
  • Peptides
  • Structure-activity relationships

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