How to make drugs orally active: A substrate template for peptide transporter PePT1

Patrick D. Bailey; C. A R Boyd; J. Ramsey Bronk; Ian D. Collier; David Meredith; Keith M. Morgan; Catherine S. Temple

How to make drugs orally active: A substrate template for peptide transporter PePT1

Patrick D. Bailey, C. A R Boyd, J. Ramsey Bronk, Ian D. Collier, David Meredith, Keith M. Morgan, Catherine S. Temple

School of Engineering & Physical Sciences

Research output: Contribution to journal › Article › peer-review

105 Citations (Scopus)

Abstract

By building key structural features into hydrophilic drugs, they can be recognized by the PepT1 transporter system of the small intestine and rendered orally active. The model shown provides, for the first time, a 3D template for all known substrates of PepT1.

Original language	English
Pages (from-to)	506-508
Number of pages	3
Journal	Angewandte Chemie International Edition
Volume	39
Issue number	3
Publication status	Published - 4 Feb 2000

Keywords

Drug research
Molecular modeling
Molecular recognition
Peptides
Structure-activity relationships

Cite this

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title = "How to make drugs orally active: A substrate template for peptide transporter PePT1",

abstract = "By building key structural features into hydrophilic drugs, they can be recognized by the PepT1 transporter system of the small intestine and rendered orally active. The model shown provides, for the first time, a 3D template for all known substrates of PepT1.",

keywords = "Drug research, Molecular modeling, Molecular recognition, Peptides, Structure-activity relationships",

author = "Bailey, {Patrick D.} and Boyd, {C. A R} and Bronk, {J. Ramsey} and Collier, {Ian D.} and David Meredith and Morgan, {Keith M.} and Temple, {Catherine S.}",

year = "2000",

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T2 - A substrate template for peptide transporter PePT1

AU - Bailey, Patrick D.

AU - Boyd, C. A R

AU - Bronk, J. Ramsey

AU - Collier, Ian D.

AU - Meredith, David

AU - Morgan, Keith M.

AU - Temple, Catherine S.

PY - 2000/2/4

Y1 - 2000/2/4

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AB - By building key structural features into hydrophilic drugs, they can be recognized by the PepT1 transporter system of the small intestine and rendered orally active. The model shown provides, for the first time, a 3D template for all known substrates of PepT1.

KW - Drug research

KW - Molecular modeling

KW - Molecular recognition

KW - Peptides

KW - Structure-activity relationships

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M3 - Article

SN - 1521-3773

VL - 39

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EP - 508

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

IS - 3

ER -

How to make drugs orally active: A substrate template for peptide transporter PePT1

Abstract

Keywords

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