Hind-limb unloading in rodents: Current evidence and perspectives

Anna Hawliczek; Bianca Brix; Shamma Al Mutawa; Hanan Alsuwaidi; Stefan Du Plessis; Yunfang Gao; Rizwan Qaisar; Ruqaiyyah Siddiqui; Adel B. Elmoselhi; Nandu Goswami

doi:10.1016/j.actaastro.2022.03.008

Hind-limb unloading in rodents: Current evidence and perspectives

Anna Hawliczek, Bianca Brix, Shamma Al Mutawa, Hanan Alsuwaidi, Stefan Du Plessis, Yunfang Gao, Rizwan Qaisar, Ruqaiyyah Siddiqui, Adel B. Elmoselhi, Nandu Goswami^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Due to scarcity of available biological samples from returning space explorers, alternative models, which improve the understanding of spaceflight-related pathophysiology are needed. This review presents an update of available literature on the hind-limb unloading model (HLU). HLU has been used as a model to simulating microgravity in rodents since the early 1980s. This model, by removing the gravitational load from hind limbs of the animals, is widely used for studying the effects of the hindlimb unloading on the cardiovascular and musculoskeletal physiology. Recent updates in the literature with regards to HLU, its advantages as well as how this model can be used to understand the effects of bedrest confinement and/or spaceflight are provided.

Original language	English
Pages (from-to)	574-582
Number of pages	9
Journal	Acta Astronautica
Volume	195
Early online date	7 Mar 2022
DOIs	https://doi.org/10.1016/j.actaastro.2022.03.008
Publication status	Published - Jun 2022

Keywords

Cardiovascular changes
Hind-limb unloading model
Immunity
Microbiome
Microgravity
Musculoskeletal changes
Stress

ASJC Scopus subject areas

Aerospace Engineering

Access to Document

10.1016/j.actaastro.2022.03.008

Cite this

@article{7639d258d91c47568c47d36f95d3348a,

title = "Hind-limb unloading in rodents: Current evidence and perspectives",

abstract = "Due to scarcity of available biological samples from returning space explorers, alternative models, which improve the understanding of spaceflight-related pathophysiology are needed. This review presents an update of available literature on the hind-limb unloading model (HLU). HLU has been used as a model to simulating microgravity in rodents since the early 1980s. This model, by removing the gravitational load from hind limbs of the animals, is widely used for studying the effects of the hindlimb unloading on the cardiovascular and musculoskeletal physiology. Recent updates in the literature with regards to HLU, its advantages as well as how this model can be used to understand the effects of bedrest confinement and/or spaceflight are provided.",

keywords = "Cardiovascular changes, Hind-limb unloading model, Immunity, Microbiome, Microgravity, Musculoskeletal changes, Stress",

author = "Anna Hawliczek and Bianca Brix and {Al Mutawa}, Shamma and Hanan Alsuwaidi and {Du Plessis}, Stefan and Yunfang Gao and Rizwan Qaisar and Ruqaiyyah Siddiqui and Elmoselhi, {Adel B.} and Nandu Goswami",

note = "Publisher Copyright: {\textcopyright} 2022",

year = "2022",

month = jun,

doi = "10.1016/j.actaastro.2022.03.008",

language = "English",

volume = "195",

pages = "574--582",

journal = "Acta Astronautica",

issn = "0094-5765",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Hind-limb unloading in rodents: Current evidence and perspectives

AU - Hawliczek, Anna

AU - Brix, Bianca

AU - Al Mutawa, Shamma

AU - Alsuwaidi, Hanan

AU - Du Plessis, Stefan

AU - Gao, Yunfang

AU - Qaisar, Rizwan

AU - Siddiqui, Ruqaiyyah

AU - Elmoselhi, Adel B.

AU - Goswami, Nandu

PY - 2022/6

Y1 - 2022/6

N2 - Due to scarcity of available biological samples from returning space explorers, alternative models, which improve the understanding of spaceflight-related pathophysiology are needed. This review presents an update of available literature on the hind-limb unloading model (HLU). HLU has been used as a model to simulating microgravity in rodents since the early 1980s. This model, by removing the gravitational load from hind limbs of the animals, is widely used for studying the effects of the hindlimb unloading on the cardiovascular and musculoskeletal physiology. Recent updates in the literature with regards to HLU, its advantages as well as how this model can be used to understand the effects of bedrest confinement and/or spaceflight are provided.

AB - Due to scarcity of available biological samples from returning space explorers, alternative models, which improve the understanding of spaceflight-related pathophysiology are needed. This review presents an update of available literature on the hind-limb unloading model (HLU). HLU has been used as a model to simulating microgravity in rodents since the early 1980s. This model, by removing the gravitational load from hind limbs of the animals, is widely used for studying the effects of the hindlimb unloading on the cardiovascular and musculoskeletal physiology. Recent updates in the literature with regards to HLU, its advantages as well as how this model can be used to understand the effects of bedrest confinement and/or spaceflight are provided.

KW - Cardiovascular changes

KW - Hind-limb unloading model

KW - Immunity

KW - Microbiome

KW - Microgravity

KW - Musculoskeletal changes

KW - Stress

UR - http://www.scopus.com/inward/record.url?scp=85126067456&partnerID=8YFLogxK

U2 - 10.1016/j.actaastro.2022.03.008

DO - 10.1016/j.actaastro.2022.03.008

M3 - Article

AN - SCOPUS:85126067456

SN - 0094-5765

VL - 195

SP - 574

EP - 582

JO - Acta Astronautica

JF - Acta Astronautica

ER -

Hind-limb unloading in rodents: Current evidence and perspectives

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this