High-throughput microfluidics for evaluating microbubble enhanced delivery of cancer therapeutics in spheroid cultures

Matthew D. Bourn, Damien V. B. Batchelor, Nicola Ingram, James McLaughlan, P. Louise Coletta, Stephen D. Evans, Sally A. Peyman*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper reports a new microfluidic device containing an array of spheroids traps, into which multiple pre-grown colorectal cancer (CRC) spheroids were loaded and exposed to therapeutics under constant flow. Reservoirs interfaced with the chip use hydrostatic pressure to passively drive flow through the system and subject spheroids to capillary like flow velocities. This system was subsequently used to observe microbubble (MB) enhanced drug delivery of both free and liposomal (LS) doxorubicin (DOX), under constant flow for the first time. Results showed increased drug accumulation and decreased spheroid viability when conventional drug treatments were combined with MB therapy.
Original languageEnglish
Title of host publication24th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2020
PublisherChemical and Biological Microsystems Society
Pages1254-1255
Number of pages2
ISBN (Electronic)9781733419017
Publication statusPublished - 2020
Event24th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2020 - Virtual, Online
Duration: 4 Oct 20209 Oct 2020

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2020
Abbreviated titleMicroTAS 2020
CityVirtual, Online
Period4/10/209/10/20

Keywords

  • Drug delivery
  • Microbubbles
  • Microfluidics
  • Spheroid Trap
  • Tumour-on-chip

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering
  • General Chemistry
  • Control and Systems Engineering

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