Abstract
This paper reports a new microfluidic device containing an array of spheroids traps, into which multiple pre-grown colorectal cancer (CRC) spheroids were loaded and exposed to therapeutics under constant flow. Reservoirs interfaced with the chip use hydrostatic pressure to passively drive flow through the system and subject spheroids to capillary like flow velocities. This system was subsequently used to observe microbubble (MB) enhanced drug delivery of both free and liposomal (LS) doxorubicin (DOX), under constant flow for the first time. Results showed increased drug accumulation and decreased spheroid viability when conventional drug treatments were combined with MB therapy.
Original language | English |
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Title of host publication | 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2020 |
Publisher | Chemical and Biological Microsystems Society |
Pages | 1254-1255 |
Number of pages | 2 |
ISBN (Electronic) | 9781733419017 |
Publication status | Published - 2020 |
Event | 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2020 - Virtual, Online Duration: 4 Oct 2020 → 9 Oct 2020 |
Conference
Conference | 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2020 |
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Abbreviated title | MicroTAS 2020 |
City | Virtual, Online |
Period | 4/10/20 → 9/10/20 |
Keywords
- Drug delivery
- Microbubbles
- Microfluidics
- Spheroid Trap
- Tumour-on-chip
ASJC Scopus subject areas
- Chemical Engineering (miscellaneous)
- Bioengineering
- General Chemistry
- Control and Systems Engineering