High throughput fabrication of microdroplets using needle based microfluidic system

Zheng Lian, Yong Ren, Kai Seng Koh, Jun He, George Zheng Chen, Xiaogang Yang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Needle-based microfluidic system that comprised of needle-based microfluidic devices (NBMD) in parallel connection was employed to generate polydimethylsiloxane (PDMS) microdroplets using oil-in-water (O/W) single emulsion template. The parallel-connection could be simply realized by multiple single NBMD connected via flow diverting devices. The versatile flow diverting devices could not only avoid the additional use of injection pumps for introducing fluids into the microfluidic system, but also enhance the yields of microdroplets. The entire production rate of the system has been raised to 535 drops per minute compared with that using a single NBMD which yields to 133 drops per minute. All the microdroplets were produced under dripping flow regime. If identical flow conditions and channel diameters were applied, the generated microdroplets from the each microchannel could have high monodispersity. Despite of several parameters that could affect the droplet sizes, for example, flow rate exerted on each channel and the channel size which depended on the selection of various needle combinations of the inlet and outlet needles, the inter-needle distance between those two needles may significantly influence the size of droplets. Thus, it shall be controlled carefully to remain the same distance in terms of achieving high monodispersity of the droplet sizes. On the other hand, one can vary the sizes of needles applied in the same batch of production or by adjusting the inter-needle distance in order to realize the production of microdroplets with various sizes. Moreover, diverse types of microdroplets could be produced simultaneously through different channels by NBMD. In this research, sugar and multi-walled carbon nanotubes (CNTs) were utilized as dopants mixing with PDMS precursor as the dispersed phase to produce PDMS-S and PDMS-CNTs microdroplets. The droplets could be collected and thermally solidified off-site for other applications. This platform does not require sophisticated equipment and is very cost-effective compared with conventional microfluidic devices such as PDMS devices or glass capillary devices. Hence, the system has great potential to produce microdroplets at a large scale.

Original languageEnglish
Title of host publicationASME 2019 6th International Conference on Micro/Nanoscale Heat and Mass Transfer
PublisherAmerican Society of Mechanical Engineers
ISBN (Electronic)9780791858905
DOIs
Publication statusPublished - 2019
Event6th International Conference on Micro/Nanoscale Heat and Mass Transfer 2019 - Dalian, China
Duration: 8 Jul 201910 Jul 2019

Conference

Conference6th International Conference on Micro/Nanoscale Heat and Mass Transfer 2019
Abbreviated titleMNHMT 2019
CountryChina
CityDalian
Period8/07/1910/07/19

ASJC Scopus subject areas

  • Fluid Flow and Transfer Processes

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  • Cite this

    Lian, Z., Ren, Y., Koh, K. S., He, J., Chen, G. Z., & Yang, X. (2019). High throughput fabrication of microdroplets using needle based microfluidic system. In ASME 2019 6th International Conference on Micro/Nanoscale Heat and Mass Transfer American Society of Mechanical Engineers. https://doi.org/10.1115/MNHMT2019-4263