High production rates of stable drug-loadable microbubbles toward targetted, triggared drug delivery

S. A. Peyman; Radwa Abou-Saleh; Nicola Ingram; Gemma Marston; P. Louise Coletta; Stephen D. Evans

High production rates of stable drug-loadable microbubbles toward targetted, triggared drug delivery

S. A. Peyman, Radwa Abou-Saleh, Nicola Ingram, Gemma Marston, P. Louise Coletta, Stephen D. Evans^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Micron-sized bubbles of gas have been used commercially as contrast agents for ultrasound (US) for over 30 years. Recently interest has increased in combing the diagnostic imaging qualities of microbubbles (MBs) with drug delivery technology to produce new treatments for cancer. We have demonstrated a microfluidic device for producing drug-loaded MBs at high, clinically relevant concentrations (10⁹ MB / mL) within 10 minutes. Currently, we report the potential for delivery of hydrophobic drugs by incorporating oil structures within the MB shell or attachment to the MB surface and in addition, an improvement in in vitro MB lifetime from 1 hour to over 5 hours at 37°C.

Original language	English
Title of host publication	17th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2013
Publisher	Chemical and Biological Microsystems Society
Pages	521-523
Number of pages	3
ISBN (Print)	9781632666246
Publication status	Published - 2013
Event	17th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2013 - Freiburg, Germany Duration: 27 Oct 2013 → 31 Oct 2013

Conference

Conference	17th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2013
Abbreviated title	MicroTAS 2013
Country/Territory	Germany
City	Freiburg
Period	27/10/13 → 31/10/13

Keywords

Drug delivery
Hydrophobic delivery
Microbubbles

ASJC Scopus subject areas

Bioengineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "High production rates of stable drug-loadable microbubbles toward targetted, triggared drug delivery",

abstract = "Micron-sized bubbles of gas have been used commercially as contrast agents for ultrasound (US) for over 30 years. Recently interest has increased in combing the diagnostic imaging qualities of microbubbles (MBs) with drug delivery technology to produce new treatments for cancer. We have demonstrated a microfluidic device for producing drug-loaded MBs at high, clinically relevant concentrations (109 MB / mL) within 10 minutes. Currently, we report the potential for delivery of hydrophobic drugs by incorporating oil structures within the MB shell or attachment to the MB surface and in addition, an improvement in in vitro MB lifetime from 1 hour to over 5 hours at 37°C.",

keywords = "Drug delivery, Hydrophobic delivery, Microbubbles",

author = "Peyman, {S. A.} and Radwa Abou-Saleh and Nicola Ingram and Gemma Marston and Coletta, {P. Louise} and Evans, {Stephen D.}",

year = "2013",

language = "English",

isbn = "9781632666246",

pages = "521--523",

booktitle = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2013",

publisher = "Chemical and Biological Microsystems Society",

note = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2013, MicroTAS 2013 ; Conference date: 27-10-2013 Through 31-10-2013",

}

Peyman, SA, Abou-Saleh, R, Ingram, N, Marston, G, Coletta, PL & Evans, SD 2013, High production rates of stable drug-loadable microbubbles toward targetted, triggared drug delivery. in 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2013. Chemical and Biological Microsystems Society, pp. 521-523, 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2013, Freiburg, Baden-Württemberg, Germany, 27/10/13.

High production rates of stable drug-loadable microbubbles toward targetted, triggared drug delivery. / Peyman, S. A.; Abou-Saleh, Radwa; Ingram, Nicola et al.
17th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2013. Chemical and Biological Microsystems Society, 2013. p. 521-523.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - High production rates of stable drug-loadable microbubbles toward targetted, triggared drug delivery

AU - Peyman, S. A.

AU - Abou-Saleh, Radwa

AU - Ingram, Nicola

AU - Marston, Gemma

AU - Coletta, P. Louise

AU - Evans, Stephen D.

PY - 2013

Y1 - 2013

N2 - Micron-sized bubbles of gas have been used commercially as contrast agents for ultrasound (US) for over 30 years. Recently interest has increased in combing the diagnostic imaging qualities of microbubbles (MBs) with drug delivery technology to produce new treatments for cancer. We have demonstrated a microfluidic device for producing drug-loaded MBs at high, clinically relevant concentrations (109 MB / mL) within 10 minutes. Currently, we report the potential for delivery of hydrophobic drugs by incorporating oil structures within the MB shell or attachment to the MB surface and in addition, an improvement in in vitro MB lifetime from 1 hour to over 5 hours at 37°C.

AB - Micron-sized bubbles of gas have been used commercially as contrast agents for ultrasound (US) for over 30 years. Recently interest has increased in combing the diagnostic imaging qualities of microbubbles (MBs) with drug delivery technology to produce new treatments for cancer. We have demonstrated a microfluidic device for producing drug-loaded MBs at high, clinically relevant concentrations (109 MB / mL) within 10 minutes. Currently, we report the potential for delivery of hydrophobic drugs by incorporating oil structures within the MB shell or attachment to the MB surface and in addition, an improvement in in vitro MB lifetime from 1 hour to over 5 hours at 37°C.

KW - Drug delivery

KW - Hydrophobic delivery

KW - Microbubbles

UR - http://www.scopus.com/inward/record.url?scp=84907344511&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:84907344511

SN - 9781632666246

SP - 521

EP - 523

BT - 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2013

PB - Chemical and Biological Microsystems Society

T2 - 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2013

Y2 - 27 October 2013 through 31 October 2013

ER -

High production rates of stable drug-loadable microbubbles toward targetted, triggared drug delivery

Abstract

Conference

Keywords

ASJC Scopus subject areas

UN SDGs

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Cite this