Halothane-induced sleeping time in the mouse

Its modification by benzodiazepines

D M Chambers, Gordon C Jefferson, C A Ruddick

Research output: Contribution to journalArticle

Abstract

The conditions under which prolongation of halothane-induced sleeping time in the mouse may be used as a test for centrally acting drugs are described. The test can be recommended for its practical advantages over methods using barbiturates to induce hypnosis; due cognizance must be taken of a diurnal variation in the response of mice to halothane. To assess the usefulness of the test the effects of amphetamine, chlorpromazine, histamine, morphine, nikethamide, pentobarbitone and SKF 525A have been investigated. The interaction between 5 benzodiazepines and halothane has been studied in particular. Results from sleeping time experiments, measurements of body temperature and of brain halothane concentrations suggest that the halothane-benzodiazepine interaction is due to additive CNS depressant effects. It was found that nitrazepam and diazepam were clearly more potent than chlorodiazepoxide, medazepam and oxazepam in respect of their interactions with halothane.

Original languageEnglish
Pages (from-to)103-112
Number of pages10
JournalEuropean Journal of Pharmacology
Volume50
Issue number2
Publication statusPublished - 1978

Fingerprint

body temperature
diurnal variation
brain
drug
test
experiment
effect
method

Cite this

Chambers, D. M., Jefferson, G. C., & Ruddick, C. A. (1978). Halothane-induced sleeping time in the mouse: Its modification by benzodiazepines. European Journal of Pharmacology, 50(2), 103-112.
Chambers, D M ; Jefferson, Gordon C ; Ruddick, C A. / Halothane-induced sleeping time in the mouse : Its modification by benzodiazepines. In: European Journal of Pharmacology. 1978 ; Vol. 50, No. 2. pp. 103-112.
@article{0978fc92e1754b7b9a123f6d4fc9383d,
title = "Halothane-induced sleeping time in the mouse: Its modification by benzodiazepines",
abstract = "The conditions under which prolongation of halothane-induced sleeping time in the mouse may be used as a test for centrally acting drugs are described. The test can be recommended for its practical advantages over methods using barbiturates to induce hypnosis; due cognizance must be taken of a diurnal variation in the response of mice to halothane. To assess the usefulness of the test the effects of amphetamine, chlorpromazine, histamine, morphine, nikethamide, pentobarbitone and SKF 525A have been investigated. The interaction between 5 benzodiazepines and halothane has been studied in particular. Results from sleeping time experiments, measurements of body temperature and of brain halothane concentrations suggest that the halothane-benzodiazepine interaction is due to additive CNS depressant effects. It was found that nitrazepam and diazepam were clearly more potent than chlorodiazepoxide, medazepam and oxazepam in respect of their interactions with halothane.",
author = "Chambers, {D M} and Jefferson, {Gordon C} and Ruddick, {C A}",
year = "1978",
language = "English",
volume = "50",
pages = "103--112",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "2",

}

Chambers, DM, Jefferson, GC & Ruddick, CA 1978, 'Halothane-induced sleeping time in the mouse: Its modification by benzodiazepines', European Journal of Pharmacology, vol. 50, no. 2, pp. 103-112.

Halothane-induced sleeping time in the mouse : Its modification by benzodiazepines. / Chambers, D M; Jefferson, Gordon C; Ruddick, C A.

In: European Journal of Pharmacology, Vol. 50, No. 2, 1978, p. 103-112.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Halothane-induced sleeping time in the mouse

T2 - Its modification by benzodiazepines

AU - Chambers, D M

AU - Jefferson, Gordon C

AU - Ruddick, C A

PY - 1978

Y1 - 1978

N2 - The conditions under which prolongation of halothane-induced sleeping time in the mouse may be used as a test for centrally acting drugs are described. The test can be recommended for its practical advantages over methods using barbiturates to induce hypnosis; due cognizance must be taken of a diurnal variation in the response of mice to halothane. To assess the usefulness of the test the effects of amphetamine, chlorpromazine, histamine, morphine, nikethamide, pentobarbitone and SKF 525A have been investigated. The interaction between 5 benzodiazepines and halothane has been studied in particular. Results from sleeping time experiments, measurements of body temperature and of brain halothane concentrations suggest that the halothane-benzodiazepine interaction is due to additive CNS depressant effects. It was found that nitrazepam and diazepam were clearly more potent than chlorodiazepoxide, medazepam and oxazepam in respect of their interactions with halothane.

AB - The conditions under which prolongation of halothane-induced sleeping time in the mouse may be used as a test for centrally acting drugs are described. The test can be recommended for its practical advantages over methods using barbiturates to induce hypnosis; due cognizance must be taken of a diurnal variation in the response of mice to halothane. To assess the usefulness of the test the effects of amphetamine, chlorpromazine, histamine, morphine, nikethamide, pentobarbitone and SKF 525A have been investigated. The interaction between 5 benzodiazepines and halothane has been studied in particular. Results from sleeping time experiments, measurements of body temperature and of brain halothane concentrations suggest that the halothane-benzodiazepine interaction is due to additive CNS depressant effects. It was found that nitrazepam and diazepam were clearly more potent than chlorodiazepoxide, medazepam and oxazepam in respect of their interactions with halothane.

M3 - Article

VL - 50

SP - 103

EP - 112

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 2

ER -