Genetic copy number variation and general cognitive ability

Andrew K MacLeod; Gail Davies; Antony Payton; Albert Tenesa; Sarah E Harris; David Liewald; Xiayi Ke; Michelle Luciano; Lorna M Lopez; Alan J Gow; Janie Corley; Paul Redmond; Geraldine McNeill; Andrew Pickles; William Ollier; Michael Horan; John M Starr; Neil Pendleton; Pippa A Thomson; David J Porteous; Ian J Deary

doi:10.1371/journal.pone.0037385

Genetic copy number variation and general cognitive ability

Andrew K MacLeod, Gail Davies, Antony Payton, Albert Tenesa, Sarah E Harris, David Liewald, Xiayi Ke, Michelle Luciano, Lorna M Lopez, Alan J Gow, Janie Corley, Paul Redmond, Geraldine McNeill, Andrew Pickles, William Ollier, Michael Horan, John M Starr, Neil Pendleton, Pippa A Thomson, David J PorteousIan J Deary

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Differences in genomic structure between individuals are ubiquitous features of human genetic variation. Specific copy number variants (CNVs) have been associated with susceptibility to numerous complex psychiatric disorders, including attention-deficit-hyperactivity disorder, autism-spectrum disorders and schizophrenia. These disorders often display co-morbidity with low intelligence. Rare chromosomal deletions and duplications are associated with these disorders, so it has been suggested that these deletions or duplications may be associated with differences in intelligence. Here we investigate associations between large (=500kb), rare (

Original language	English
Pages (from-to)	e37385
Journal	PLoS ONE
Volume	7
Issue number	12
DOIs	https://doi.org/10.1371/journal.pone.0037385
Publication status	Published - 2012

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MacLeod, A. K., Davies, G., Payton, A., Tenesa, A., Harris, S. E., Liewald, D., Ke, X., Luciano, M., Lopez, L. M., Gow, A. J., Corley, J., Redmond, P., McNeill, G., Pickles, A., Ollier, W., Horan, M., Starr, J. M., Pendleton, N., Thomson, P. A., ... Deary, I. J. (2012). Genetic copy number variation and general cognitive ability. PLoS ONE, 7(12), e37385. https://doi.org/10.1371/journal.pone.0037385

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abstract = "Differences in genomic structure between individuals are ubiquitous features of human genetic variation. Specific copy number variants (CNVs) have been associated with susceptibility to numerous complex psychiatric disorders, including attention-deficit-hyperactivity disorder, autism-spectrum disorders and schizophrenia. These disorders often display co-morbidity with low intelligence. Rare chromosomal deletions and duplications are associated with these disorders, so it has been suggested that these deletions or duplications may be associated with differences in intelligence. Here we investigate associations between large (=500kb), rare (",

author = "MacLeod, {Andrew K} and Gail Davies and Antony Payton and Albert Tenesa and Harris, {Sarah E} and David Liewald and Xiayi Ke and Michelle Luciano and Lopez, {Lorna M} and Gow, {Alan J} and Janie Corley and Paul Redmond and Geraldine McNeill and Andrew Pickles and William Ollier and Michael Horan and Starr, {John M} and Neil Pendleton and Thomson, {Pippa A} and Porteous, {David J} and Deary, {Ian J}",

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MacLeod, AK, Davies, G, Payton, A, Tenesa, A, Harris, SE, Liewald, D, Ke, X, Luciano, M, Lopez, LM, Gow, AJ, Corley, J, Redmond, P, McNeill, G, Pickles, A, Ollier, W, Horan, M, Starr, JM, Pendleton, N, Thomson, PA, Porteous, DJ & Deary, IJ 2012, 'Genetic copy number variation and general cognitive ability', PLoS ONE, vol. 7, no. 12, pp. e37385. https://doi.org/10.1371/journal.pone.0037385

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T1 - Genetic copy number variation and general cognitive ability

AU - MacLeod, Andrew K

AU - Davies, Gail

AU - Payton, Antony

AU - Tenesa, Albert

AU - Harris, Sarah E

AU - Liewald, David

AU - Ke, Xiayi

AU - Luciano, Michelle

AU - Lopez, Lorna M

AU - Gow, Alan J

AU - Corley, Janie

AU - Redmond, Paul

AU - McNeill, Geraldine

AU - Pickles, Andrew

AU - Ollier, William

AU - Horan, Michael

AU - Starr, John M

AU - Pendleton, Neil

AU - Thomson, Pippa A

AU - Porteous, David J

AU - Deary, Ian J

PY - 2012

Y1 - 2012

N2 - Differences in genomic structure between individuals are ubiquitous features of human genetic variation. Specific copy number variants (CNVs) have been associated with susceptibility to numerous complex psychiatric disorders, including attention-deficit-hyperactivity disorder, autism-spectrum disorders and schizophrenia. These disorders often display co-morbidity with low intelligence. Rare chromosomal deletions and duplications are associated with these disorders, so it has been suggested that these deletions or duplications may be associated with differences in intelligence. Here we investigate associations between large (=500kb), rare (

AB - Differences in genomic structure between individuals are ubiquitous features of human genetic variation. Specific copy number variants (CNVs) have been associated with susceptibility to numerous complex psychiatric disorders, including attention-deficit-hyperactivity disorder, autism-spectrum disorders and schizophrenia. These disorders often display co-morbidity with low intelligence. Rare chromosomal deletions and duplications are associated with these disorders, so it has been suggested that these deletions or duplications may be associated with differences in intelligence. Here we investigate associations between large (=500kb), rare (

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DO - 10.1371/journal.pone.0037385

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SN - 1932-6203

VL - 7

SP - e37385

JO - PLoS ONE

JF - PLoS ONE

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ER -

Genetic copy number variation and general cognitive ability

Abstract

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