Gastrointestinal diagnosis using non-white light imaging capsule endoscopy

Gerard Cummins, Benjamin F. Cox, Gastone Ciuti, Thineskrishna Anbarasan, Marc Phillipe Yves Desmulliez, Sandy Cochran, Robert Steele, John N. Plevris, Anastasios Koulaouzidis

Research output: Contribution to journalReview articlepeer-review

34 Citations (Scopus)
563 Downloads (Pure)


Capsule endoscopy (CE) has proved to be a powerful tool in the diagnosis and management of small bowel disorders since its introduction in 2001. However, white light imaging (WLI) is the principal technology used in clinical CE at present, and therefore, CE is limited to mucosal inspection, with diagnosis remaining reliant on visible manifestations of disease. The introduction of WLI CE has motivated a wide range of research to improve its diagnostic capabilities through integration with other sensing modalities. These developments have the potential to overcome the limitations of WLI through enhanced detection of subtle mucosal microlesions and submucosal and/or transmural pathology, providing novel diagnostic avenues. Other research aims to utilize a range of sensors to measure physiological parameters or to discover new biomarkers to improve the sensitivity, specificity and thus the clinical utility of CE. This multidisciplinary Review summarizes research into non-WLI CE devices by organizing them into a taxonomic structure on the basis of their sensing modality. The potential of these capsules to realize clinically useful virtual biopsy and computer-aided diagnosis (CADx) is also reported.
Original languageEnglish
Pages (from-to)429-447
Number of pages19
JournalNature Reviews Gastroenterology and Hepatology
Early online date15 Apr 2019
Publication statusPublished - Jul 2019

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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