Frugal filtering optical lenses for point-of-care diagnostics

Joanna Long, Helen E. Parker, Katjana Ehrlich, Michael G. Tanner, Kevin Dhaliwal, Bethany Mills

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Abstract

Infectious diseases are the leading cause of morbidity and mortality in low and middle income countries (LMICs). Rapid diagnosis of infections in LMICs presents many challenges, especially in rural areas where access to health care, including diagnostics, is poor. Microscopy is one of the most commonly used platforms to diagnose bacterial infections on clinical samples. Fluorescence microscopy has high sensitivity and specificity but to date is mostly performed within a laboratory setting due to the high-cost, low portability and highly specialist nature of equipment. Point-of-care diagnostics could offer a solution to the challenge of infection diagnosis in LMICs. In this paper we present frugal, easy to manufacture, doped polydimethylsiloxane filtering optical lenses that can be integrated into smartphone microscopes for immediate detection of fluorescently labelled bacteria. This provides a breakthrough technology platform for point-of-care diagnostics.
Original languageEnglish
Pages (from-to)1864-1875
Number of pages12
JournalBiomedical Optics Express
Volume11
Issue number4
Early online date9 Mar 2020
DOIs
Publication statusPublished - 1 Apr 2020

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    Long, J., Parker, H. E., Ehrlich, K., Tanner, M. G., Dhaliwal, K., & Mills, B. (2020). Frugal filtering optical lenses for point-of-care diagnostics. Biomedical Optics Express, 11(4), 1864-1875. https://doi.org/10.1364/BOE.381014