From chemical mixtures to picoliter droplet libraries: Harnessing concentration gradients with droplet-based microfludics

A. B. Theberge, G. B. Whyte, W. T. S. Huck

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Chemical separations play an important role across the chemical and life sciences, and many applications could benefit from the ability to process the separated products in a miniaturized and automated fashion for further downstream manipulation and detection. By interfacing nano-flow ultra performance liquid chromatography (UPLC) with droplet-based microfluidics, we have developed a method to produce libraries of picoliter droplets containing pure compounds at a range of concentrations spanning two to three orders of magnitude, starting from chemical mixtures. Moreover since the droplet libraries are produced in a microfluidic device, each droplet is individually addressable for further manipulation and interrogation on chip.

Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010
Pages1103-1105
Number of pages3
Publication statusPublished - 2010
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010 - Groningen, Netherlands
Duration: 3 Oct 20107 Oct 2010

Conference

Conference14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010
Abbreviated titleMicroTAS 2010
CountryNetherlands
CityGroningen
Period3/10/107/10/10

Keywords

  • Compartmentali-zation
  • Droplet-based Microfluidics
  • Separation
  • Ultra Performance Liquid Chromatography

ASJC Scopus subject areas

  • Control and Systems Engineering

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