Abstract
Chemical separations play an important role across the chemical and life sciences, and many applications could benefit from the ability to process the separated products in a miniaturized and automated fashion for further downstream manipulation and detection. By interfacing nano-flow ultra performance liquid chromatography (UPLC) with droplet-based microfluidics, we have developed a method to produce libraries of picoliter droplets containing pure compounds at a range of concentrations spanning two to three orders of magnitude, starting from chemical mixtures. Moreover since the droplet libraries are produced in a microfluidic device, each droplet is individually addressable for further manipulation and interrogation on chip.
Original language | English |
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Title of host publication | 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010 |
Pages | 1103-1105 |
Number of pages | 3 |
Publication status | Published - 2010 |
Event | 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010 - Groningen, Netherlands Duration: 3 Oct 2010 → 7 Oct 2010 |
Conference
Conference | 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010 |
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Abbreviated title | MicroTAS 2010 |
Country/Territory | Netherlands |
City | Groningen |
Period | 3/10/10 → 7/10/10 |
Keywords
- Compartmentali-zation
- Droplet-based Microfluidics
- Separation
- Ultra Performance Liquid Chromatography
ASJC Scopus subject areas
- Control and Systems Engineering