Forming oil layer inside microbubbles through single step microfluidics, towards hydrophobic drug delivery

A. H. Churchman; V. Mico; J. Gala de Pablo; S. A. Peyman; S. D. Evans

Forming oil layer inside microbubbles through single step microfluidics, towards hydrophobic drug delivery

A. H. Churchman, V. Mico, J. Gala de Pablo, S. A. Peyman, S. D. Evans^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

This paper reports a new and simple one-step method for the formation of hydrophobic drug delivery capsules with echogenic properties, termed oil layer inside microbubbles (OLI-MBs). There is a growing need to design delivery vehicles for hydrophobic drug since many new drugs have poor water solubility. We show that we are able to produce on-chip OLI-MBs at a clinically relevant size and use Fluorescent Resonant Energy Transfer (FRET) to confirm the oil layer.

Original language	English
Title of host publication	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2016
Publisher	Chemical and Biological Microsystems Society
Pages	750-751
Number of pages	2
ISBN (Electronic)	9780979806490
Publication status	Published - 2016
Event	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2016 - Dublin, Ireland Duration: 9 Oct 2016 → 13 Oct 2016

Conference

Conference	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2016
Abbreviated title	MicroTAS 2016
Country/Territory	Ireland
City	Dublin
Period	9/10/16 → 13/10/16

Keywords

Drug delivery
FRET
Hydrophobic
Microbubble
Nanodroplet

ASJC Scopus subject areas

Control and Systems Engineering

Cite this

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title = "Forming oil layer inside microbubbles through single step microfluidics, towards hydrophobic drug delivery",

abstract = "This paper reports a new and simple one-step method for the formation of hydrophobic drug delivery capsules with echogenic properties, termed oil layer inside microbubbles (OLI-MBs). There is a growing need to design delivery vehicles for hydrophobic drug since many new drugs have poor water solubility. We show that we are able to produce on-chip OLI-MBs at a clinically relevant size and use Fluorescent Resonant Energy Transfer (FRET) to confirm the oil layer.",

keywords = "Drug delivery, FRET, Hydrophobic, Microbubble, Nanodroplet",

author = "Churchman, {A. H.} and V. Mico and {Gala de Pablo}, J. and Peyman, {S. A.} and Evans, {S. D.}",

year = "2016",

language = "English",

pages = "750--751",

booktitle = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2016",

publisher = "Chemical and Biological Microsystems Society",

note = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2016, MicroTAS 2016 ; Conference date: 09-10-2016 Through 13-10-2016",

}

Churchman, AH, Mico, V, Gala de Pablo, J, Peyman, SA & Evans, SD 2016, Forming oil layer inside microbubbles through single step microfluidics, towards hydrophobic drug delivery. in 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2016. Chemical and Biological Microsystems Society, pp. 750-751, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2016, Dublin, Ireland, 9/10/16.

Forming oil layer inside microbubbles through single step microfluidics, towards hydrophobic drug delivery. / Churchman, A. H.; Mico, V.; Gala de Pablo, J. et al.
20th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2016. Chemical and Biological Microsystems Society, 2016. p. 750-751.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Forming oil layer inside microbubbles through single step microfluidics, towards hydrophobic drug delivery

AU - Churchman, A. H.

AU - Mico, V.

AU - Gala de Pablo, J.

AU - Peyman, S. A.

AU - Evans, S. D.

PY - 2016

Y1 - 2016

N2 - This paper reports a new and simple one-step method for the formation of hydrophobic drug delivery capsules with echogenic properties, termed oil layer inside microbubbles (OLI-MBs). There is a growing need to design delivery vehicles for hydrophobic drug since many new drugs have poor water solubility. We show that we are able to produce on-chip OLI-MBs at a clinically relevant size and use Fluorescent Resonant Energy Transfer (FRET) to confirm the oil layer.

AB - This paper reports a new and simple one-step method for the formation of hydrophobic drug delivery capsules with echogenic properties, termed oil layer inside microbubbles (OLI-MBs). There is a growing need to design delivery vehicles for hydrophobic drug since many new drugs have poor water solubility. We show that we are able to produce on-chip OLI-MBs at a clinically relevant size and use Fluorescent Resonant Energy Transfer (FRET) to confirm the oil layer.

KW - Drug delivery

KW - FRET

KW - Hydrophobic

KW - Microbubble

KW - Nanodroplet

UR - http://www.scopus.com/inward/record.url?scp=85014221870&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:85014221870

SP - 750

EP - 751

BT - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2016

PB - Chemical and Biological Microsystems Society

T2 - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2016

Y2 - 9 October 2016 through 13 October 2016

ER -

Forming oil layer inside microbubbles through single step microfluidics, towards hydrophobic drug delivery

Abstract

Conference

Keywords

ASJC Scopus subject areas

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