Fibre-based ratiometric fluorescence imaging for contrast enhancement of spectrally similar signals in the lung

Helen E. Parker, James Stone, Adam D. L. Marshall, Tushar R. Choudhary, Robert R. Thomson, Kevin Dhaliwal, Michael G. Tanner

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Abstract

We present a widefield ratiometric fibred optical endomicroscopy platform capable of enhancing contrast between spectrally similar pathologically relevant fluorophores. We demonstrate the detection of fluorescently labelled bacteria in an autofluorescent ex vivo human lung model.
Original languageEnglish
Title of host publicationClinical and Translational Biophotonics 2020
PublisherOptical Society of America
ISBN (Print)9781943580743
DOIs
Publication statusPublished - 2020

Keywords

  • Endomicroscopy
  • Fiber bundles
  • Fluorescence
  • Fluorescence lifetime imaging
  • Image processing
  • In vivo imaging

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    Parker, H. E., Stone, J., Marshall, A. D. L., Choudhary, T. R., Thomson, R. R., Dhaliwal, K., & Tanner, M. G. (2020). Fibre-based ratiometric fluorescence imaging for contrast enhancement of spectrally similar signals in the lung. In Clinical and Translational Biophotonics 2020 [TTu2B.4] Optical Society of America. https://doi.org/10.1364/TRANSLATIONAL.2020.TTu2B.4