Fast Fiber Orientation Estimation in Diffusion MRI from kq-Space Sampling and Anatomical Priors

Marica Pesce, Audrey Repetti, Anna Auria, Alessandro Daducci, Jean-Philippe Thiran, Yves Wiaux

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
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High spatio-angular resolution diffusion MRI (dMRI) has been shown to provide accurate identification of complex neuronal fiber configurations, albeit, at the cost of long acquisition times. We propose a method to recover intra-voxel fiber configurations at high spatio-angular resolution relying on a 3D kq-space under-sampling scheme to enable accelerated acquisitions. The inverse problem for the reconstruction of the fiber orientation distribution (FOD) is regularized by a structured sparsity prior promoting simultaneously voxel-wise sparsity and spatial smoothness of fiber orientation. Prior knowledge of the spatial distribution of white matter, gray matter, and cerebrospinal fluid is also leveraged. A minimization problem is formulated and solved via a stochastic forward–backward algorithm. Simulations and real data analysis suggest that accurate FOD mapping can be achieved from severe kq-space under-sampling regimes potentially enabling high spatio-angular resolution dMRI in the clinical setting.
Original languageEnglish
Article number226
JournalJournal of Imaging
Issue number11
Early online date27 Oct 2021
Publication statusPublished - Nov 2021


  • Compressed sensing
  • Data acquisition
  • Diffusion MRI
  • Optimization
  • Reconstruction

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Computer Vision and Pattern Recognition
  • Computer Graphics and Computer-Aided Design
  • Electrical and Electronic Engineering


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