High spatio-angular resolution diffusion MRI (dMRI) has been shown to provide accurate identification of complex neuronal fiber configurations, albeit at the cost of long acquisition times. We propose a method to recover intra-voxel fiber configurations at high spatio-angular resolution relying on a 3D kq-space under-sampling scheme to enable accelerated acquisitions. The inverse problem for the reconstruction of the fiber orientation distribution (FOD) is regularized by a structured sparsity prior promoting simultaneously voxelwise sparsity and spatial smoothness of fiber orientation. Prior knowledge of the spatial distribution of white matter, gray matter and cerebrospinal fluid is also leveraged. A minimization problem is formulated and solved via a stochastic forward-backward algorithm. Simulations and real data analysis suggest that accurate FOD mapping can be achieved from severe kq-space under-sampling regimes, potentially enabling high spatio-angular resolution dMRI in the clinical setting.
|Number of pages||25|
|Journal||Journal of Imaging|
|Publication status||Accepted/In press - 10 Aug 2021|