Abstract
We report a fast evaporation aided coating method to coat vaccines onto densely packed and very small microprojection containing patches which are used to efficiently deliver vaccines to the antigen presenting cells in the dermis/epidermis of the skin. Increased evaporation speed of coating solution aids localization of the vaccines on the distal tips of microprojections that penetrate into the skin; rather than to the backing and to the base of the microprojections. Therefore, the delivered efficiency of coated vaccine is increased. This method further improves the dose reduction effects we already observed with this novel patch design. This method of coating therefore will help to make more vaccine doses available in a case of a pandemic, help reduce the cost of the vaccines and provides a platform for future vaccines.
Original language | English |
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Title of host publication | ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology |
Place of Publication | Piscataway (New Jersey) |
Publisher | IEEE |
Pages | 358-361 |
Number of pages | 4 |
ISBN (Print) | 9781424452620 |
DOIs | |
Publication status | Published - 2010 |
Event | 3rd International Conference on Nanoscience and Nanotechnology 2010 - Sydney, NSW, Australia Duration: 22 Feb 2010 → 26 Feb 2010 |
Conference
Conference | 3rd International Conference on Nanoscience and Nanotechnology 2010 |
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Abbreviated title | ICONN 2010 |
Country/Territory | Australia |
City | Sydney, NSW |
Period | 22/02/10 → 26/02/10 |
Keywords
- Delivery efficiency
- Fast evaporation
- Microprojections
- Vaccine
ASJC Scopus subject areas
- Biotechnology
- Bioengineering