Fast evaporation aided coating of densely packed and short microprojection patches for enhanced vaccine delivery to the skin

X. Chen, G. J P Fernando, H. Corbett, T. W. Prow, M. L. Crichton, M. A.F. Crichton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We report a fast evaporation aided coating method to coat vaccines onto densely packed and very small microprojection containing patches which are used to efficiently deliver vaccines to the antigen presenting cells in the dermis/epidermis of the skin. Increased evaporation speed of coating solution aids localization of the vaccines on the distal tips of microprojections that penetrate into the skin; rather than to the backing and to the base of the microprojections. Therefore, the delivered efficiency of coated vaccine is increased. This method further improves the dose reduction effects we already observed with this novel patch design. This method of coating therefore will help to make more vaccine doses available in a case of a pandemic, help reduce the cost of the vaccines and provides a platform for future vaccines.

Original languageEnglish
Title of host publicationICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology
Place of PublicationPiscataway (New Jersey)
PublisherIEEE
Pages358-361
Number of pages4
ISBN (Print)9781424452620
DOIs
Publication statusPublished - 2010
Event3rd International Conference on Nanoscience and Nanotechnology 2010 - Sydney, NSW, Australia
Duration: 22 Feb 201026 Feb 2010

Conference

Conference3rd International Conference on Nanoscience and Nanotechnology 2010
Abbreviated titleICONN 2010
CountryAustralia
CitySydney, NSW
Period22/02/1026/02/10

Keywords

  • Delivery efficiency
  • Fast evaporation
  • Microprojections
  • Vaccine

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

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    Chen, X., Fernando, G. J. P., Corbett, H., Prow, T. W., Crichton, M. L., & Crichton, M. A. F. (2010). Fast evaporation aided coating of densely packed and short microprojection patches for enhanced vaccine delivery to the skin. In ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology (pp. 358-361). [6045237] IEEE. https://doi.org/10.1109/ICONN.2010.6045237