Fast evaporation aided coating of densely packed and short microprojection patches for enhanced vaccine delivery to the skin

X. Chen; G. J P Fernando; H. Corbett; T. W. Prow; M. L. Crichton; M. A.F. Crichton

doi:10.1109/ICONN.2010.6045237

Fast evaporation aided coating of densely packed and short microprojection patches for enhanced vaccine delivery to the skin

X. Chen^*, G. J P Fernando, H. Corbett, T. W. Prow, M. L. Crichton, M. A.F. Crichton

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We report a fast evaporation aided coating method to coat vaccines onto densely packed and very small microprojection containing patches which are used to efficiently deliver vaccines to the antigen presenting cells in the dermis/epidermis of the skin. Increased evaporation speed of coating solution aids localization of the vaccines on the distal tips of microprojections that penetrate into the skin; rather than to the backing and to the base of the microprojections. Therefore, the delivered efficiency of coated vaccine is increased. This method further improves the dose reduction effects we already observed with this novel patch design. This method of coating therefore will help to make more vaccine doses available in a case of a pandemic, help reduce the cost of the vaccines and provides a platform for future vaccines.

Original language	English
Title of host publication	ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology
Place of Publication	Piscataway (New Jersey)
Publisher	IEEE
Pages	358-361
Number of pages	4
ISBN (Print)	9781424452620
DOIs	https://doi.org/10.1109/ICONN.2010.6045237
Publication status	Published - 2010
Event	3rd International Conference on Nanoscience and Nanotechnology 2010 - Sydney, NSW, Australia Duration: 22 Feb 2010 → 26 Feb 2010

Conference

Conference	3rd International Conference on Nanoscience and Nanotechnology 2010
Abbreviated title	ICONN 2010
Country/Territory	Australia
City	Sydney, NSW
Period	22/02/10 → 26/02/10

Keywords

Delivery efficiency
Fast evaporation
Microprojections
Vaccine

ASJC Scopus subject areas

Biotechnology
Bioengineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1109/ICONN.2010.6045237

Cite this

Chen, X., Fernando, G. J. P., Corbett, H., Prow, T. W., Crichton, M. L., & Crichton, M. A. F. (2010). Fast evaporation aided coating of densely packed and short microprojection patches for enhanced vaccine delivery to the skin. In ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology (pp. 358-361). Article 6045237 IEEE. https://doi.org/10.1109/ICONN.2010.6045237

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title = "Fast evaporation aided coating of densely packed and short microprojection patches for enhanced vaccine delivery to the skin",

abstract = "We report a fast evaporation aided coating method to coat vaccines onto densely packed and very small microprojection containing patches which are used to efficiently deliver vaccines to the antigen presenting cells in the dermis/epidermis of the skin. Increased evaporation speed of coating solution aids localization of the vaccines on the distal tips of microprojections that penetrate into the skin; rather than to the backing and to the base of the microprojections. Therefore, the delivered efficiency of coated vaccine is increased. This method further improves the dose reduction effects we already observed with this novel patch design. This method of coating therefore will help to make more vaccine doses available in a case of a pandemic, help reduce the cost of the vaccines and provides a platform for future vaccines.",

keywords = "Delivery efficiency, Fast evaporation, Microprojections, Vaccine",

author = "X. Chen and Fernando, {G. J P} and H. Corbett and Prow, {T. W.} and Crichton, {M. L.} and Crichton, {M. A.F.}",

year = "2010",

doi = "10.1109/ICONN.2010.6045237",

language = "English",

isbn = "9781424452620",

pages = "358--361",

booktitle = "ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology",

publisher = "IEEE",

address = "United States",

note = "3rd International Conference on Nanoscience and Nanotechnology 2010, ICONN 2010 ; Conference date: 22-02-2010 Through 26-02-2010",

}

Chen, X, Fernando, GJP, Corbett, H, Prow, TW, Crichton, ML & Crichton, MAF 2010, Fast evaporation aided coating of densely packed and short microprojection patches for enhanced vaccine delivery to the skin. in ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology., 6045237, IEEE, Piscataway (New Jersey), pp. 358-361, 3rd International Conference on Nanoscience and Nanotechnology 2010, Sydney, NSW, Australia, 22/02/10. https://doi.org/10.1109/ICONN.2010.6045237

Fast evaporation aided coating of densely packed and short microprojection patches for enhanced vaccine delivery to the skin. / Chen, X.; Fernando, G. J P; Corbett, H. et al.
ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology. Piscataway (New Jersey): IEEE, 2010. p. 358-361 6045237.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Fast evaporation aided coating of densely packed and short microprojection patches for enhanced vaccine delivery to the skin

AU - Chen, X.

AU - Fernando, G. J P

AU - Corbett, H.

AU - Prow, T. W.

AU - Crichton, M. L.

AU - Crichton, M. A.F.

PY - 2010

Y1 - 2010

N2 - We report a fast evaporation aided coating method to coat vaccines onto densely packed and very small microprojection containing patches which are used to efficiently deliver vaccines to the antigen presenting cells in the dermis/epidermis of the skin. Increased evaporation speed of coating solution aids localization of the vaccines on the distal tips of microprojections that penetrate into the skin; rather than to the backing and to the base of the microprojections. Therefore, the delivered efficiency of coated vaccine is increased. This method further improves the dose reduction effects we already observed with this novel patch design. This method of coating therefore will help to make more vaccine doses available in a case of a pandemic, help reduce the cost of the vaccines and provides a platform for future vaccines.

AB - We report a fast evaporation aided coating method to coat vaccines onto densely packed and very small microprojection containing patches which are used to efficiently deliver vaccines to the antigen presenting cells in the dermis/epidermis of the skin. Increased evaporation speed of coating solution aids localization of the vaccines on the distal tips of microprojections that penetrate into the skin; rather than to the backing and to the base of the microprojections. Therefore, the delivered efficiency of coated vaccine is increased. This method further improves the dose reduction effects we already observed with this novel patch design. This method of coating therefore will help to make more vaccine doses available in a case of a pandemic, help reduce the cost of the vaccines and provides a platform for future vaccines.

KW - Delivery efficiency

KW - Fast evaporation

KW - Microprojections

KW - Vaccine

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M3 - Conference contribution

AN - SCOPUS:80555125015

SN - 9781424452620

SP - 358

EP - 361

BT - ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology

PB - IEEE

CY - Piscataway (New Jersey)

T2 - 3rd International Conference on Nanoscience and Nanotechnology 2010

Y2 - 22 February 2010 through 26 February 2010

ER -

Chen X, Fernando GJP, Corbett H, Prow TW, Crichton ML, Crichton MAF. Fast evaporation aided coating of densely packed and short microprojection patches for enhanced vaccine delivery to the skin. In ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology. Piscataway (New Jersey): IEEE. 2010. p. 358-361. 6045237 doi: 10.1109/ICONN.2010.6045237

Fast evaporation aided coating of densely packed and short microprojection patches for enhanced vaccine delivery to the skin

Abstract

Conference

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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