Fabrication and testing of microfluidic devices for blood cell separation

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Blood separation is a strategic preliminary step in preparation to on-chip biological analysis. Two microfluidic devices for on-chip blood separation are presented. Both devices will be integrated to form the separation module of a Lab on Chip for non-invasive prenatal diagnosis. In the first device, a blood plasma separator, the separation of blood cells from plasma is made possible in microchannels by bio-physical effects such as an axial migration effect and Zweifach-Fung bifurcation law. Behaviour of mussel and human blood suspensions were studied alongside the effect of different geometries. The second device aims to separate fetal nucleated red blood cells based on their magnetic susceptibility. Biocompatible materials are used in the manufacturing of both devices.
Original languageEnglish
Title of host publicationBrunel Institute for Bioengineering (BIB), The Brunel Collection
Place of PublicationBrunel, UK
PublisherBrunel University
ISBN (Electronic)978-1-902316-73-4
ISBN (Print)978-1-902316-72-7
Publication statusPublished - Sep 2009
Event2nd Micro and Nano Flows Conference - London, United Kingdom
Duration: 1 Sep 20092 Sep 2009

Conference

Conference2nd Micro and Nano Flows Conference
Abbreviated titleMNF2009
CountryUnited Kingdom
CityLondon
Period1/09/092/09/09

Keywords

  • Microfluidic devices
  • Blood separation
  • SU8
  • Microchannel

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  • Cite this

    Kavanagh, D., Kersaudy-Kerhoas, M., & Desmulliez, M. P. Y. (2009). Fabrication and testing of microfluidic devices for blood cell separation. In Brunel Institute for Bioengineering (BIB), The Brunel Collection Brunel University.