Excited-State Dynamics of a Two-Photon-Activatable Ruthenium Prodrug

Simon E. Greenough; Michael D. Horbury; Nichola A. Smith; Peter J. Sadler; Martin J Paterson; Vasilios G Stavros

doi:10.1002/cphc.201501075

Excited-State Dynamics of a Two-Photon-Activatable Ruthenium Prodrug

Simon E. Greenough, Michael D. Horbury, Nichola A. Smith, Peter J. Sadler, Martin J Paterson, Vasilios G Stavros

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Abstract

We present a new approach to investigate how the photodynamics of an octahedral ruthenium(II) complex activated through two-photon absorption (TPA) differ from the equivalent complex activated through one-photon absorption (OPA). We photoactivated a Ru^II polypyridyl complex containing bioactive monodentate ligands in the photodynamic therapy window (620-1000nm) by using TPA and used transient UV/Vis absorption spectroscopy to elucidate its reaction pathways. Density functional calculations allowed us to identify the nature of the initially populated states and kinetic analysis recovers a photoactivation lifetime of approximately 100ps. The dynamics displayed following TPA or OPA are identical, showing that TPA prodrug design may use knowledge gathered from the more numerous and easily conducted OPA studies.

Original language	English
Pages (from-to)	221-224
Number of pages	4
Journal	ChemPhysChem
Volume	17
Issue number	2
DOIs	https://doi.org/10.1002/cphc.201501075
Publication status	Published - 18 Jan 2016

Keywords

Density functional calculations
Ligand substitution
Ruthenium
Time-resolved spectroscopy
Two-photon absorption

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Atomic and Molecular Physics, and Optics

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abstract = "We present a new approach to investigate how the photodynamics of an octahedral ruthenium(II) complex activated through two-photon absorption (TPA) differ from the equivalent complex activated through one-photon absorption (OPA). We photoactivated a RuII polypyridyl complex containing bioactive monodentate ligands in the photodynamic therapy window (620-1000nm) by using TPA and used transient UV/Vis absorption spectroscopy to elucidate its reaction pathways. Density functional calculations allowed us to identify the nature of the initially populated states and kinetic analysis recovers a photoactivation lifetime of approximately 100ps. The dynamics displayed following TPA or OPA are identical, showing that TPA prodrug design may use knowledge gathered from the more numerous and easily conducted OPA studies.",

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AU - Paterson, Martin J

AU - Stavros, Vasilios G

PY - 2016/1/18

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KW - Density functional calculations

KW - Ligand substitution

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Excited-State Dynamics of a Two-Photon-Activatable Ruthenium Prodrug

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Martin J. Paterson

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Excited-State Dynamics of a Two-Photon-Activatable Ruthenium Prodrug

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ASJC Scopus subject areas

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Martin J. Paterson

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