Examination of the Process Scale Dependence of L-Glutamic Acid Batch Crystallized from Supersaturated Aqueous Solutions in Relation to Reactor Hydrodynamics

Kangping Liang, Graeme White, Derek Wilkinson, Leslie J. Ford, Kevin J. Roberts, W. M L Wood

Research output: Contribution to journalArticle

Abstract

The effects of reactor internals and reactant mixing on the measured metastable zone width (MSZW) associated with the batch crystallization of L-glutamic acid from supersaturated aqueous solutions are presented. The results of cooling crystallization experiments, as carried out at three reactor scales (450 mL, 2 L, and 20 L) agitated at various stirring speeds using an industry-standard retreat curve impeller with a single beaver-tail baffle, are shown. The observed MSZWs are mostly found to decrease with increasing stirring speed, with enhanced nucleation also being observed as the reactor scale increased; albeit hindered nucleation was found at higher stirrer speeds in the 450-mL reactor experiments. The MSZW data are correlated with Reynolds number to reveal a model reflecting the combined influences of hydrodynamics and scale on the overall nucleation process.

Original languageEnglish
Pages (from-to)1227-1234
Number of pages8
JournalIndustrial and Engineering Chemistry Research
Volume43
Issue number5
Publication statusPublished - 3 Mar 2004

Fingerprint

aqueous solution
hydrodynamics
nucleation
acid
crystallization
Reynolds number
experiment
cooling
reactor
industry
speed

Cite this

@article{8be15e03d3554175a689cad565198da4,
title = "Examination of the Process Scale Dependence of L-Glutamic Acid Batch Crystallized from Supersaturated Aqueous Solutions in Relation to Reactor Hydrodynamics",
abstract = "The effects of reactor internals and reactant mixing on the measured metastable zone width (MSZW) associated with the batch crystallization of L-glutamic acid from supersaturated aqueous solutions are presented. The results of cooling crystallization experiments, as carried out at three reactor scales (450 mL, 2 L, and 20 L) agitated at various stirring speeds using an industry-standard retreat curve impeller with a single beaver-tail baffle, are shown. The observed MSZWs are mostly found to decrease with increasing stirring speed, with enhanced nucleation also being observed as the reactor scale increased; albeit hindered nucleation was found at higher stirrer speeds in the 450-mL reactor experiments. The MSZW data are correlated with Reynolds number to reveal a model reflecting the combined influences of hydrodynamics and scale on the overall nucleation process.",
author = "Kangping Liang and Graeme White and Derek Wilkinson and Ford, {Leslie J.} and Roberts, {Kevin J.} and Wood, {W. M L}",
year = "2004",
month = "3",
day = "3",
language = "English",
volume = "43",
pages = "1227--1234",
journal = "Industrial and Engineering Chemistry Research",
issn = "0888-5885",
publisher = "American Chemical Society",
number = "5",

}

Examination of the Process Scale Dependence of L-Glutamic Acid Batch Crystallized from Supersaturated Aqueous Solutions in Relation to Reactor Hydrodynamics. / Liang, Kangping; White, Graeme; Wilkinson, Derek; Ford, Leslie J.; Roberts, Kevin J.; Wood, W. M L.

In: Industrial and Engineering Chemistry Research, Vol. 43, No. 5, 03.03.2004, p. 1227-1234.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Examination of the Process Scale Dependence of L-Glutamic Acid Batch Crystallized from Supersaturated Aqueous Solutions in Relation to Reactor Hydrodynamics

AU - Liang, Kangping

AU - White, Graeme

AU - Wilkinson, Derek

AU - Ford, Leslie J.

AU - Roberts, Kevin J.

AU - Wood, W. M L

PY - 2004/3/3

Y1 - 2004/3/3

N2 - The effects of reactor internals and reactant mixing on the measured metastable zone width (MSZW) associated with the batch crystallization of L-glutamic acid from supersaturated aqueous solutions are presented. The results of cooling crystallization experiments, as carried out at three reactor scales (450 mL, 2 L, and 20 L) agitated at various stirring speeds using an industry-standard retreat curve impeller with a single beaver-tail baffle, are shown. The observed MSZWs are mostly found to decrease with increasing stirring speed, with enhanced nucleation also being observed as the reactor scale increased; albeit hindered nucleation was found at higher stirrer speeds in the 450-mL reactor experiments. The MSZW data are correlated with Reynolds number to reveal a model reflecting the combined influences of hydrodynamics and scale on the overall nucleation process.

AB - The effects of reactor internals and reactant mixing on the measured metastable zone width (MSZW) associated with the batch crystallization of L-glutamic acid from supersaturated aqueous solutions are presented. The results of cooling crystallization experiments, as carried out at three reactor scales (450 mL, 2 L, and 20 L) agitated at various stirring speeds using an industry-standard retreat curve impeller with a single beaver-tail baffle, are shown. The observed MSZWs are mostly found to decrease with increasing stirring speed, with enhanced nucleation also being observed as the reactor scale increased; albeit hindered nucleation was found at higher stirrer speeds in the 450-mL reactor experiments. The MSZW data are correlated with Reynolds number to reveal a model reflecting the combined influences of hydrodynamics and scale on the overall nucleation process.

UR - http://www.scopus.com/inward/record.url?scp=1342281095&partnerID=8YFLogxK

M3 - Article

VL - 43

SP - 1227

EP - 1234

JO - Industrial and Engineering Chemistry Research

JF - Industrial and Engineering Chemistry Research

SN - 0888-5885

IS - 5

ER -