Evaluation and establishment of a cleaning protocol for the production of vanisal sodium and aspirin using a continuous oscillatory baffled reactor

Caldeira Ricardo, Ni Xiongwei

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The robustness and adaptability of a continuous oscillatory baffled reactor (COBR) in organic syntheses of vanisal sodium and aspirin were tested whilst meeting the stringent regulatory standards. In one week-long continuous operation, vanisal sodium was produced to a purity level of 99.94%, aspirin to a level of 99.57%. The loss of product during the cleaning process amounted to 0.001% and 0.005% for vanisal sodium and aspirin, respectively. The data of the continuous syntheses show that the operation of the COBR is robust and consistent throughout the week-long period. The cleaning stage that was used after each production campaign exhibited a first-order kinetics and was effective and efficient. © 2009 American Chemical Society.

Original languageEnglish
Pages (from-to)1080-1087
Number of pages8
JournalOrganic Process Research and Development
Volume13
Issue number6
DOIs
Publication statusPublished - 20 Nov 2009

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