Enhanced working memory binding by direct electrical stimulation of the parietal cortex

Agustina Birba, Eugenia Hesse, Lucas Sedeño, Ezequiel P. Mikulan, Maria del Carmen García, Juan Avalos, Federico Adolfi, Tristan A. Bekinschtein, Máximo Zimerman, Mario Parra Rodriguez, Adolfo M. García, Agustín M. Ibáñez

Abstract

Recent works evince the critical role of visual short-term memory (STM) binding deficits as a clinical and preclinical marker of Alzheimer’s disease. These studies suggest a potential role of posterior brain regions in both the neurocognitive deficits of Alzheimer’s patients and STM binding in general. Thereupon, we surmised that stimulation of the posterior parietal cortex might be a successful approach to tackle working memory deficits in this condition, especially at early stages. To date, no causal evidence exists of the role of the parietal cortex in STM binding. A unique approach to assess this issue is afforded by single subject direct intracranial electrical stimulation of specific brain regions during a relevant cognitive task. Electrical stimulation has been used both for clinical purposes and to causally probe brain mechanisms. Previous evidence of electrical currents spreading through white matter along well defined functional circuits indicates that visual working memory mechanisms are subserved by a specific widely distributed network. Here, we stimulated the parietal cortex of a subject with intracranial electrodes as he performed the visual STM task. We compared the ensuing results to those from a non-stimulated condition and to the performance of a matched control group. In brief, direct stimulation of the parietal cortex induced a selective improvement in STM. These results, together with previous studies, provide very preliminary but promising ground to examine behavioral changes upon parietal stimulation in AD. We discuss our results regarding (a) the usefulness of the task to target prodromal stages of Alzheimer’s disease, (b) the role of a posterior network in STM binding and in Alzheimer’s disease, and (c) the potential opportunity to improve STM binding through brain stimulation.
Original languageEnglish
Article number178
JournalFrontiers in Aging Neuroscience
Volume9
DOIs
StatePublished - 8 Jun 2017

Fingerprint

Parietal Lobe
Short-Term Memory
Electric Stimulation
memory
brain
Alzheimer Disease
Brain
deficit
Memory Disorders
subject
network
Prodromal Symptoms
Deep Brain Stimulation
Electrodes
Research Design
Biological Markers
White Matter
measurement method
diffusion
purpose

Keywords

  • Working memory binding
  • Alzhimer´s disease
  • direct electrical stimulation
  • short term memory
  • single case study

Cite this

Birba, A., Hesse, E., Sedeño, L., Mikulan, E. P., del Carmen García, M., Avalos, J., ... Ibáñez, A. M. (2017). Enhanced working memory binding by direct electrical stimulation of the parietal cortex. Frontiers in Aging Neuroscience, 9, [178]. DOI: 10.3389/fnagi.2017.00178

Birba, Agustina; Hesse, Eugenia ; Sedeño, Lucas; Mikulan, Ezequiel P.; del Carmen García, Maria; Avalos, Juan; Adolfi, Federico; Bekinschtein, Tristan A.; Zimerman, Máximo; Parra Rodriguez, Mario; García, Adolfo M.; Ibáñez, Agustín M. / Enhanced working memory binding by direct electrical stimulation of the parietal cortex.

In: Frontiers in Aging Neuroscience, Vol. 9, 178, 08.06.2017.

Research output: Contribution to journalArticle

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author = "Agustina Birba and Eugenia Hesse and Lucas Sedeño and Mikulan, {Ezequiel P.} and {del Carmen García}, Maria and Juan Avalos and Federico Adolfi and Bekinschtein, {Tristan A.} and Máximo Zimerman and {Parra Rodriguez}, Mario and García, {Adolfo M.} and Ibáñez, {Agustín M.}",
year = "2017",
month = "6",
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Birba, A, Hesse, E, Sedeño, L, Mikulan, EP, del Carmen García, M, Avalos, J, Adolfi, F, Bekinschtein, TA, Zimerman, M, Parra Rodriguez, M, García, AM & Ibáñez, AM 2017, 'Enhanced working memory binding by direct electrical stimulation of the parietal cortex' Frontiers in Aging Neuroscience, vol 9, 178. DOI: 10.3389/fnagi.2017.00178

Enhanced working memory binding by direct electrical stimulation of the parietal cortex. / Birba, Agustina; Hesse, Eugenia ; Sedeño, Lucas; Mikulan, Ezequiel P.; del Carmen García, Maria; Avalos, Juan; Adolfi, Federico; Bekinschtein, Tristan A.; Zimerman, Máximo; Parra Rodriguez, Mario; García, Adolfo M.; Ibáñez, Agustín M.

In: Frontiers in Aging Neuroscience, Vol. 9, 178, 08.06.2017.

Research output: Contribution to journalArticle

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T1 - Enhanced working memory binding by direct electrical stimulation of the parietal cortex

AU - Birba,Agustina

AU - Hesse,Eugenia

AU - Sedeño,Lucas

AU - Mikulan,Ezequiel P.

AU - del Carmen García,Maria

AU - Avalos,Juan

AU - Adolfi,Federico

AU - Bekinschtein,Tristan A.

AU - Zimerman,Máximo

AU - Parra Rodriguez,Mario

AU - García,Adolfo M.

AU - Ibáñez,Agustín M.

PY - 2017/6/8

Y1 - 2017/6/8

N2 - Recent works evince the critical role of visual short-term memory (STM) binding deficits as a clinical and preclinical marker of Alzheimer’s disease. These studies suggest a potential role of posterior brain regions in both the neurocognitive deficits of Alzheimer’s patients and STM binding in general. Thereupon, we surmised that stimulation of the posterior parietal cortex might be a successful approach to tackle working memory deficits in this condition, especially at early stages. To date, no causal evidence exists of the role of the parietal cortex in STM binding. A unique approach to assess this issue is afforded by single subject direct intracranial electrical stimulation of specific brain regions during a relevant cognitive task. Electrical stimulation has been used both for clinical purposes and to causally probe brain mechanisms. Previous evidence of electrical currents spreading through white matter along well defined functional circuits indicates that visual working memory mechanisms are subserved by a specific widely distributed network. Here, we stimulated the parietal cortex of a subject with intracranial electrodes as he performed the visual STM task. We compared the ensuing results to those from a non-stimulated condition and to the performance of a matched control group. In brief, direct stimulation of the parietal cortex induced a selective improvement in STM. These results, together with previous studies, provide very preliminary but promising ground to examine behavioral changes upon parietal stimulation in AD. We discuss our results regarding (a) the usefulness of the task to target prodromal stages of Alzheimer’s disease, (b) the role of a posterior network in STM binding and in Alzheimer’s disease, and (c) the potential opportunity to improve STM binding through brain stimulation.

AB - Recent works evince the critical role of visual short-term memory (STM) binding deficits as a clinical and preclinical marker of Alzheimer’s disease. These studies suggest a potential role of posterior brain regions in both the neurocognitive deficits of Alzheimer’s patients and STM binding in general. Thereupon, we surmised that stimulation of the posterior parietal cortex might be a successful approach to tackle working memory deficits in this condition, especially at early stages. To date, no causal evidence exists of the role of the parietal cortex in STM binding. A unique approach to assess this issue is afforded by single subject direct intracranial electrical stimulation of specific brain regions during a relevant cognitive task. Electrical stimulation has been used both for clinical purposes and to causally probe brain mechanisms. Previous evidence of electrical currents spreading through white matter along well defined functional circuits indicates that visual working memory mechanisms are subserved by a specific widely distributed network. Here, we stimulated the parietal cortex of a subject with intracranial electrodes as he performed the visual STM task. We compared the ensuing results to those from a non-stimulated condition and to the performance of a matched control group. In brief, direct stimulation of the parietal cortex induced a selective improvement in STM. These results, together with previous studies, provide very preliminary but promising ground to examine behavioral changes upon parietal stimulation in AD. We discuss our results regarding (a) the usefulness of the task to target prodromal stages of Alzheimer’s disease, (b) the role of a posterior network in STM binding and in Alzheimer’s disease, and (c) the potential opportunity to improve STM binding through brain stimulation.

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KW - Alzhimer´s disease

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DO - 10.3389/fnagi.2017.00178

M3 - Article

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JO - Frontiers in Aging Neuroscience

T2 - Frontiers in Aging Neuroscience

JF - Frontiers in Aging Neuroscience

SN - 1663-4365

M1 - 178

ER -

Birba A, Hesse E, Sedeño L, Mikulan EP, del Carmen García M, Avalos J et al. Enhanced working memory binding by direct electrical stimulation of the parietal cortex. Frontiers in Aging Neuroscience. 2017 Jun 8;9. 178. Available from, DOI: 10.3389/fnagi.2017.00178