Engineered nanomaterial risk. Lessons learnt from completed nanotoxicology studies: potential solutions to current and future challenges

Helinor Johnston, Giulio Pojana, Stefano Zuin, Nicklas Raun Jacobsen, Peter Møller, Steffen Loft, Manuela Semmler-Behnke, Catherine McGuiness, Dominique Balharry, Antonio Marcomini, Håkan Wallin, Wolfgang Kreyling, Ken Donaldson, Lang Tran, Vicki Stone

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    Abstract

    PARTICLE_RISK was one of the first multidisciplinary projects funded by the European Commission's Framework Programme that was responsible for evaluating the implications of nanomaterial (NM) exposure on human health. This project was the basis for this review which identifies the challenges that exist within the assessment of NM risk. We have retrospectively reflected on the findings of completed nanotoxicology studies to consider what progress and advances have been made within the risk assessment of NMs, as well as discussing the direction that nanotoxicology research is taking and identifying the limitations and failings of existing research. We have reflected on what commonly encountered challenges exist and explored how these issues may be resolved. In particular, the following is discussed (i) NM selection (ii) NM physico-chemical characterisation; (iii) NM dispersion; (iv) selection of relevant doses and concentrations; (v) identification of relevant models, target sites and endpoints; (vi) development of alternatives to animal testing; and (vii) NM risk assessment. These knowledge gaps are relatively well recognised by the scientific community and recommendations as to how they may be overcome in the future are provided. It is hoped that this will help develop better defined hypothesis driven research in the future that will enable comprehensive risk assessments to be conducted for NMs. Importantly, the nanotoxicology community has responded and adapted to advances in knowledge over recent years to improve the approaches used to assess NM hazard, exposure and risk. It is vital to learn from existing information provided by ongoing or completed studies to avoid unnecessary duplication of effort, and to offer guidance on aspects of the experimental design that should be carefully considered prior to the start of a new study.
    Original languageEnglish
    Pages (from-to)1-20
    Number of pages20
    JournalCritical Reviews in Toxicology
    Volume43
    Issue number1
    DOIs
    Publication statusPublished - Jan 2013

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    Johnston, H., Pojana, G., Zuin, S., Jacobsen, N. R., Møller, P., Loft, S., Semmler-Behnke, M., McGuiness, C., Balharry, D., Marcomini, A., Wallin, H., Kreyling, W., Donaldson, K., Tran, L., & Stone, V. (2013). Engineered nanomaterial risk. Lessons learnt from completed nanotoxicology studies: potential solutions to current and future challenges. Critical Reviews in Toxicology, 43(1), 1-20. https://doi.org/10.3109/10408444.2012.738187