Endoscopic sensing of alveolar pH

Debaditya Choudhury, Michael George Tanner, Sarah McAughtrie, Fei Yu, Beth Mills, Tushar Choudhary, Sohan Seth, Tom Craven, Jim Stone, Ioulia Mati, Colin Campbell, Mark Bradley, Chris Williams, Kevin Dhaliwal, Tim Birks, Robert R. Thomson

Research output: Contribution to journalArticle

18 Citations (Scopus)
60 Downloads (Pure)

Abstract

Previously unobtainable measurements of alveolar pH were obtained using an endoscope-deployable optrode. The pH sensing was achieved using functionalized gold nanoshell sensors and surface enhanced Raman spectroscopy (SERS). The optrode consisted of an asymmetric dual-core optical fiber designed for spatially separating the optical pump delivery and signal collection, in order to circumvent the unwanted Raman signal generated within the fiber. Using this approach, we demonstrate a ~100-fold increase in SERS signal-to-fiber background ratio, and demonstrate multiple site pH sensing with a measurement accuracy of ± 0.07 pH units in the respiratory acini of an ex vivo ovine lung model. We also demonstrate that alveolar pH changes in response to ventilation.
Original languageEnglish
Pages (from-to)243-259
Number of pages17
JournalBiomedical Optics Express
Volume8
Issue number1
Early online date13 Dec 2016
DOIs
Publication statusPublished - 1 Jan 2017

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    Choudhury, D., Tanner, M. G., McAughtrie, S., Yu, F., Mills, B., Choudhary, T., Seth, S., Craven, T., Stone, J., Mati, I., Campbell, C., Bradley, M., Williams, C., Dhaliwal, K., Birks, T., & Thomson, R. R. (2017). Endoscopic sensing of alveolar pH. Biomedical Optics Express, 8(1), 243-259. https://doi.org/10.1364/BOE.8.000243