TY - JOUR
T1 - Endoscopic sensing of alveolar pH
AU - Choudhury, Debaditya
AU - Tanner, Michael George
AU - McAughtrie, Sarah
AU - Yu, Fei
AU - Mills, Beth
AU - Choudhary, Tushar
AU - Seth, Sohan
AU - Craven, Tom
AU - Stone, Jim
AU - Mati, Ioulia
AU - Campbell, Colin
AU - Bradley, Mark
AU - Williams, Chris
AU - Dhaliwal, Kevin
AU - Birks, Tim
AU - Thomson, Robert R.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Previously unobtainable measurements of alveolar pH were obtained using an endoscope-deployable optrode. The pH sensing was achieved using functionalized gold nanoshell sensors and surface enhanced Raman spectroscopy (SERS). The optrode consisted of an asymmetric dual-core optical fiber designed for spatially separating the optical pump delivery and signal collection, in order to circumvent the unwanted Raman signal generated within the fiber. Using this approach, we demonstrate a ~100-fold increase in SERS signal-to-fiber background ratio, and demonstrate multiple site pH sensing with a measurement accuracy of ± 0.07 pH units in the respiratory acini of an ex vivo ovine lung model. We also demonstrate that alveolar pH changes in response to ventilation.
AB - Previously unobtainable measurements of alveolar pH were obtained using an endoscope-deployable optrode. The pH sensing was achieved using functionalized gold nanoshell sensors and surface enhanced Raman spectroscopy (SERS). The optrode consisted of an asymmetric dual-core optical fiber designed for spatially separating the optical pump delivery and signal collection, in order to circumvent the unwanted Raman signal generated within the fiber. Using this approach, we demonstrate a ~100-fold increase in SERS signal-to-fiber background ratio, and demonstrate multiple site pH sensing with a measurement accuracy of ± 0.07 pH units in the respiratory acini of an ex vivo ovine lung model. We also demonstrate that alveolar pH changes in response to ventilation.
U2 - 10.1364/BOE.8.000243
DO - 10.1364/BOE.8.000243
M3 - Article
C2 - 28101415
SN - 2156-7085
VL - 8
SP - 243
EP - 259
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 1
ER -