Endoscopic sensing of alveolar pH

Debaditya Choudhury; Michael George Tanner; Sarah McAughtrie; Fei Yu; Beth Mills; Tushar Choudhary; Sohan Seth; Tom  Craven; Jim Stone; Ioulia Mati; Colin Campbell; Mark Bradley; Chris Williams; Kevin Dhaliwal; Tim Birks; Robert R. Thomson

doi:10.1364/BOE.8.000243

Endoscopic sensing of alveolar pH

Debaditya Choudhury, Michael George Tanner, Sarah McAughtrie, Fei Yu, Beth Mills, Tushar Choudhary, Sohan Seth, Tom Craven, Jim Stone, Ioulia Mati, Colin Campbell, Mark Bradley, Chris Williams, Kevin Dhaliwal, Tim Birks, Robert R. Thomson

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Abstract

Previously unobtainable measurements of alveolar pH were obtained using an endoscope-deployable optrode. The pH sensing was achieved using functionalized gold nanoshell sensors and surface enhanced Raman spectroscopy (SERS). The optrode consisted of an asymmetric dual-core optical fiber designed for spatially separating the optical pump delivery and signal collection, in order to circumvent the unwanted Raman signal generated within the fiber. Using this approach, we demonstrate a ~100-fold increase in SERS signal-to-fiber background ratio, and demonstrate multiple site pH sensing with a measurement accuracy of ± 0.07 pH units in the respiratory acini of an ex vivo ovine lung model. We also demonstrate that alveolar pH changes in response to ventilation.

Original language	English
Pages (from-to)	243-259
Number of pages	17
Journal	Biomedical Optics Express
Volume	8
Issue number	1
Early online date	13 Dec 2016
DOIs	https://doi.org/10.1364/BOE.8.000243
Publication status	Published - 1 Jan 2017

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AU - Choudhury, Debaditya

AU - Tanner, Michael George

AU - McAughtrie, Sarah

AU - Yu, Fei

AU - Mills, Beth

AU - Choudhary, Tushar

AU - Seth, Sohan

AU - Craven, Tom

AU - Stone, Jim

AU - Mati, Ioulia

AU - Campbell, Colin

AU - Bradley, Mark

AU - Williams, Chris

AU - Dhaliwal, Kevin

AU - Birks, Tim

AU - Thomson, Robert R.

PY - 2017/1/1

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AB - Previously unobtainable measurements of alveolar pH were obtained using an endoscope-deployable optrode. The pH sensing was achieved using functionalized gold nanoshell sensors and surface enhanced Raman spectroscopy (SERS). The optrode consisted of an asymmetric dual-core optical fiber designed for spatially separating the optical pump delivery and signal collection, in order to circumvent the unwanted Raman signal generated within the fiber. Using this approach, we demonstrate a ~100-fold increase in SERS signal-to-fiber background ratio, and demonstrate multiple site pH sensing with a measurement accuracy of ± 0.07 pH units in the respiratory acini of an ex vivo ovine lung model. We also demonstrate that alveolar pH changes in response to ventilation.

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Endoscopic sensing of alveolar pH

Abstract

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