In Vitro acoustic characterization of three phospholipid ultrasound contrast agents from 12 to 43 MHz

Chao Sun, Vassilis Sboros, Mairead B Butler, Carmel M Moran

Research output: Contribution to journalArticle

Abstract

The acoustic properties of two clinical (Definity, Lantheus Medical Imaging, North Billerica, MA, USA; SonoVue, Bracco S. P. A., Milan, Italy) and one pre-clinical (MicroMarker, untargeted, Bracco, Geneva, Switzerland; VisualSonics, Toronto, ON, Canada) ultrasound contrast agent were characterized using a broadband substitution technique over the ultrasound frequency range 12-43 MHz at 20 +/- 1 degrees C. At the same number concentration, the acoustic attenuation and contrast-to-tissue ratio of the three native ultrasound contrast agents are comparable at frequencies below 30 MHz, though their size distributions and encapsulated gases and shells differ. At frequencies above 30 MHz, native MicroMarker has higher attenuation values and contrast-to-tissue ratios than native Definity and SonoVue. Decantation was found to be an effective method to alter the size distribution and concentration of native clinical microbubble populations, enabling further contrast enhancement for specific pre-clinical applications. (E-mail: carmel.moran@ed.ac.uk) (C) 2014 World Federation for Ultrasound in Medicine & Biology.

Original languageEnglish
Pages (from-to)541-550
Number of pages10
JournalUltrasound in Medicine and Biology
Volume40
Issue number3
DOIs
Publication statusPublished - Mar 2014

Keywords

  • High-frequency ultrasound
  • Microbubble
  • Attenuation
  • Contrast-to-tissue ratio
  • Pre-clinical
  • Decantation
  • HIGH-FREQUENCY ULTRASOUND
  • SIZE DISTRIBUTION
  • MICROBUBBLE-SIZE
  • VIVO
  • DEFINITY(TM)
  • MICE
  • ATTENUATION
  • BEHAVIOR

Cite this

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title = "In Vitro acoustic characterization of three phospholipid ultrasound contrast agents from 12 to 43 MHz",
abstract = "The acoustic properties of two clinical (Definity, Lantheus Medical Imaging, North Billerica, MA, USA; SonoVue, Bracco S. P. A., Milan, Italy) and one pre-clinical (MicroMarker, untargeted, Bracco, Geneva, Switzerland; VisualSonics, Toronto, ON, Canada) ultrasound contrast agent were characterized using a broadband substitution technique over the ultrasound frequency range 12-43 MHz at 20 +/- 1 degrees C. At the same number concentration, the acoustic attenuation and contrast-to-tissue ratio of the three native ultrasound contrast agents are comparable at frequencies below 30 MHz, though their size distributions and encapsulated gases and shells differ. At frequencies above 30 MHz, native MicroMarker has higher attenuation values and contrast-to-tissue ratios than native Definity and SonoVue. Decantation was found to be an effective method to alter the size distribution and concentration of native clinical microbubble populations, enabling further contrast enhancement for specific pre-clinical applications. (E-mail: carmel.moran@ed.ac.uk) (C) 2014 World Federation for Ultrasound in Medicine & Biology.",
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In Vitro acoustic characterization of three phospholipid ultrasound contrast agents from 12 to 43 MHz. / Sun, Chao; Sboros, Vassilis; Butler, Mairead B; Moran, Carmel M.

In: Ultrasound in Medicine and Biology, Vol. 40, No. 3, 03.2014, p. 541-550.

Research output: Contribution to journalArticle

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