This article reports the first results of a Nafion®-based, solid state, non-volatile, electronically reconfigurable Radio Frequency (RF)-switch integrated to a co-planar waveguide transmission line (CPW) in shunt mode, on a flexible paper substrate. The switch is based on a metal–insulator–metal structure formed respectively using Silver–Nafion–aluminum switching layers. The presented device is fully passive and shows good performance till 3 GHz, with an insertion loss less than 3 dB in the RF-on state and isolation greater than 15 dB in the RF-off state. Low-power direct current pulses in the range 10 V/0.5 mA and −20 V/0.15 A are used to operate the switch. The device was fabricated in an ambient laboratory condition, without the use of any clean room facilities. A brief discussion of the results and potential application of this concept in a re-configurable chipless RFID tag is also given in this article. This study is a proof of concept of fabrication of electronically re-configurable and disposable RF-electronic switches on low cost and flexible substrates, using a process feasible for mass production.