Effects of Water and Temperature on Reaction Mechanism and Crystal Properties in a Reactive Crystallization of Paracetamol

Meifen Jiang, Xiongwei Ni

Research output: Contribution to journalArticle

2 Citations (Scopus)
225 Downloads (Pure)

Abstract

By considering both reaction and crystallization of paracetamol as a single process for the purpose of continuous operation, the solubility for crystallization was firstly optimized, from which suitable concentrations of reagents for the reaction were then determined. The effects of water content and reaction temperature on reaction kinetics and mechanism as well as crystal properties were jointly investigated, for the first time, using chromatographic methods; paracetamol form I particles with high purity (99%) were produced with the presence of water, while 4′-acetoxyacetanilide was the main product in the absence of water.
Original languageEnglish
Pages (from-to)20-26
Number of pages7
JournalChemical Engineering and Processing: Process Intensification
Volume131
Early online date9 Jul 2018
DOIs
Publication statusPublished - Sep 2018

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