Abstract
By considering both reaction and crystallization of paracetamol as a single process for the purpose of continuous operation, the solubility for crystallization was firstly optimized, from which suitable concentrations of reagents for the reaction were then determined. The effects of water content and reaction temperature on reaction kinetics and mechanism as well as crystal properties were jointly investigated, for the first time, using chromatographic methods; paracetamol form I particles with high purity (99%) were produced with the presence of water, while 4′-acetoxyacetanilide was the main product in the absence of water.
| Original language | English |
|---|---|
| Pages (from-to) | 20-26 |
| Number of pages | 7 |
| Journal | Chemical Engineering and Processing: Process Intensification |
| Volume | 131 |
| Early online date | 9 Jul 2018 |
| DOIs | |
| Publication status | Published - Sept 2018 |
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Dive into the research topics of 'Effects of Water and Temperature on Reaction Mechanism and Crystal Properties in a Reactive Crystallization of Paracetamol'. Together they form a unique fingerprint.Profiles
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Xiongwei Ni
- School of Engineering & Physical Sciences - Professor
- School of Engineering & Physical Sciences, Institute of Mechanical, Process & Energy Engineering - Professor
- School of Engineering & Physical Sciences, Institute of Chemical Sciences - Professor
Person: Academic (Research & Teaching)