Effects of drug pretreatment on antipyrine elimination in the rabbit

D M Chambers, Gordon C Jefferson

Research output: Contribution to journalArticle

Abstract

Iproniazid (25-100 mg/kg) produced a marked, dose related reduction in antipyrine elimination in the rabbit, whereas reductions produced by nitrazepam (32 mg/kg) or SKF 525A (25 and 40 mg/kg) were small. Phenobarbitone, 10 mg/kg chronically, increased antipyrine elimination. The small inhibitory effect of SKF 525A on antipyrine metabolism in the rabbit was unexpected compared to the marked effect in the rat.

Original languageEnglish
Pages (from-to)88-95
Number of pages8
JournalPharmacology
Volume24
Issue number2
Publication statusPublished - 1982

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