Effects of drug pretreatment on antipyrine elimination in the rabbit

D M Chambers, Gordon C Jefferson

Research output: Contribution to journalArticle

Abstract

Iproniazid (25-100 mg/kg) produced a marked, dose related reduction in antipyrine elimination in the rabbit, whereas reductions produced by nitrazepam (32 mg/kg) or SKF 525A (25 and 40 mg/kg) were small. Phenobarbitone, 10 mg/kg chronically, increased antipyrine elimination. The small inhibitory effect of SKF 525A on antipyrine metabolism in the rabbit was unexpected compared to the marked effect in the rat.

Original languageEnglish
Pages (from-to)88-95
Number of pages8
JournalPharmacology
Volume24
Issue number2
Publication statusPublished - 1982

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Antipyrine
Proadifen
Rabbits
Iproniazid
Nitrazepam
Pharmaceutical Preparations
Phenobarbital

Cite this

Chambers, D. M., & Jefferson, G. C. (1982). Effects of drug pretreatment on antipyrine elimination in the rabbit. Pharmacology, 24(2), 88-95.
Chambers, D M ; Jefferson, Gordon C. / Effects of drug pretreatment on antipyrine elimination in the rabbit. In: Pharmacology. 1982 ; Vol. 24, No. 2. pp. 88-95.
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Chambers, DM & Jefferson, GC 1982, 'Effects of drug pretreatment on antipyrine elimination in the rabbit', Pharmacology, vol. 24, no. 2, pp. 88-95.

Effects of drug pretreatment on antipyrine elimination in the rabbit. / Chambers, D M; Jefferson, Gordon C.

In: Pharmacology, Vol. 24, No. 2, 1982, p. 88-95.

Research output: Contribution to journalArticle

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