Effects of ascorbic acid and disodium edetate on the stability of isoprenaline hydrochloride injection

G Smith, K Hasson, J A Clements

    Research output: Contribution to journalArticle

    Abstract

    Disodium edetate (0.01%), either alone or in combination with ascorbic acid (0.1%) was an effective stabilizer for isoprenaline injection B.P. but adjustment to pH 2.8 was necessary. The bubbling of nitrogen through the solution in the ampoule before sealing did not prevent degradation in unprotected solutions. Solutions sterilized by filtration or by autoclaving for 30 min at 116°C were stable for at least 1 year at 5°C or 25°C.

    Original languageEnglish
    Pages (from-to)209-215
    Number of pages7
    JournalJournal of Clinical and Hospital Pharmacy
    Volume9
    Issue number3
    Publication statusPublished - 1984

    Fingerprint Dive into the research topics of 'Effects of ascorbic acid and disodium edetate on the stability of isoprenaline hydrochloride injection'. Together they form a unique fingerprint.

    Cite this