Disodium edetate (0.01%), either alone or in combination with ascorbic acid (0.1%) was an effective stabilizer for isoprenaline injection B.P. but adjustment to pH 2.8 was necessary. The bubbling of nitrogen through the solution in the ampoule before sealing did not prevent degradation in unprotected solutions. Solutions sterilized by filtration or by autoclaving for 30 min at 116°C were stable for at least 1 year at 5°C or 25°C.
|Number of pages||7|
|Journal||Journal of Clinical and Hospital Pharmacy|
|Publication status||Published - 1984|