TY - JOUR
T1 - Effects of Aerobic Exercise on Systemic Insulin Degludec Concentrations in People With Type 1 Diabetes
AU - Herzig, David
AU - Groessl, Michael
AU - Álvarez-Martínez, Mario
AU - Reverter-Branchat, Gemma
AU - Nakas, Christos T.
AU - Kosinski, Christophe
AU - Stettler, Christoph
AU - Bally, Lia
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The study was supported by the UDEM Research Fund, the University of Bern, the Diabetes Center Bern and an ISS (Investigator Sponsored Studies) program of Novo Nordisk A/S, Denmark. MAM received financial support from the Engineering and Physical Sciences Research Council (EPSRC). The supporting entities were not involved in the design of the study; the collection, analysis, and interpretation of data; writing the report, and did not impose any restriction regarding the publication of the report.
Publisher Copyright:
© 2021 Diabetes Technology Society.
PY - 2023/1
Y1 - 2023/1
N2 - Background: There is conflicting evidence on the effect of exercise on systemic insulin concentrations in adults with type 1 diabetes.Methods: This prospective single-arm study examined the effect of exercise on systemic insulin degludec (IDeg) concentrations. The study involved 15 male adults with type 1 diabetes (age 30.7 ± 8.0 years, HbA1c 6.9 ± 0.7%) on stable IDeg regimen. Blood samples were collected every 15 minutes at rest, during 60 minutes of cycling (66% VO 2max) and until 90 minutes after exercise termination. IDeg concentrations were quantified using high-resolution mass-spectrometry and analyzed applying generalized estimation equations.Results: Compared to baseline, systemic IDeg increased during exercise over time (P <.001), with the highest concentrations observed toward the end of the 60-minute exercise (17.9% and 17.6% above baseline after 45 minutes and 60 minutes, respectively). IDeg levels remained elevated until the end of the experiment (14% above baseline at 90 minutes after exercise termination, P <.001).Conclusions: A single bout of aerobic exercise increases systemic IDeg exposure in adults on a stable basal IDeg regimen. This finding may have important implications for future hypoglycemia mitigation strategies around physical exercise in IDeg-treated patients.
AB - Background: There is conflicting evidence on the effect of exercise on systemic insulin concentrations in adults with type 1 diabetes.Methods: This prospective single-arm study examined the effect of exercise on systemic insulin degludec (IDeg) concentrations. The study involved 15 male adults with type 1 diabetes (age 30.7 ± 8.0 years, HbA1c 6.9 ± 0.7%) on stable IDeg regimen. Blood samples were collected every 15 minutes at rest, during 60 minutes of cycling (66% VO 2max) and until 90 minutes after exercise termination. IDeg concentrations were quantified using high-resolution mass-spectrometry and analyzed applying generalized estimation equations.Results: Compared to baseline, systemic IDeg increased during exercise over time (P <.001), with the highest concentrations observed toward the end of the 60-minute exercise (17.9% and 17.6% above baseline after 45 minutes and 60 minutes, respectively). IDeg levels remained elevated until the end of the experiment (14% above baseline at 90 minutes after exercise termination, P <.001).Conclusions: A single bout of aerobic exercise increases systemic IDeg exposure in adults on a stable basal IDeg regimen. This finding may have important implications for future hypoglycemia mitigation strategies around physical exercise in IDeg-treated patients.
KW - exercise
KW - high-resolution mass spectrometry
KW - insulin degludec
KW - type 1 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85116330773&partnerID=8YFLogxK
U2 - 10.1177/19322968211043915
DO - 10.1177/19322968211043915
M3 - Article
C2 - 34590906
SN - 1932-2968
VL - 17
SP - 172
EP - 175
JO - Journal of Diabetes Science and Technology
JF - Journal of Diabetes Science and Technology
IS - 1
ER -
