Effect of ligand substitution on DNA binding ability of two new square planar copper(II)-Schiff base complexes

Dipali Sadhukhan, Aurkie Ray, Saurabh Das, Corrado Rizzoli, Georgina M. Rosair, Samiran Mitra

Research output: Contribution to journalArticle

Abstract

Two terdentate NNO donor Schiff base ligands CH3C(OH){double bond, long}CHC(CH3){double bond, long}NCH2C5H4N [HL1] and C6H5C(OH){double bond, long}CHC(CH3){double bond, long}NCH2C5H4N [HL2] were used to synthesize two mononuclear square planar copper(II) complexes, [CuL1(CF3COO)] (1) and [CuL2(CF3COO)] (2). The complexes were characterized by elemental analyses, FT-IR, UV-vis spectral methods and their structures were established by single crystal X-ray diffraction study. The biochemical activity of the complexes towards DNA binding were performed using absorbance and fluorescence titration methods and their mode of binding with calf thymus DNA has been established by viscosity measurement technique. © 2010 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)265-273
Number of pages9
JournalJournal of Molecular Structure
Volume975
Issue number1-3
DOIs
Publication statusPublished - 30 Jun 2010

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Schiff Bases
Viscosity measurement
Titration
Copper
Substitution reactions
Fluorescence
Single crystals
Ligands
X ray diffraction
DNA
calf thymus DNA

Keywords

  • Bifurcated H-bonding
  • Copper(II) complexes
  • CT-DNA
  • Hypochromism
  • Intercalation
  • Square planarity

Cite this

Sadhukhan, Dipali ; Ray, Aurkie ; Das, Saurabh ; Rizzoli, Corrado ; Rosair, Georgina M. ; Mitra, Samiran. / Effect of ligand substitution on DNA binding ability of two new square planar copper(II)-Schiff base complexes. In: Journal of Molecular Structure. 2010 ; Vol. 975, No. 1-3. pp. 265-273.
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Effect of ligand substitution on DNA binding ability of two new square planar copper(II)-Schiff base complexes. / Sadhukhan, Dipali; Ray, Aurkie; Das, Saurabh; Rizzoli, Corrado; Rosair, Georgina M.; Mitra, Samiran.

In: Journal of Molecular Structure, Vol. 975, No. 1-3, 30.06.2010, p. 265-273.

Research output: Contribution to journalArticle

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AU - Ray, Aurkie

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