Effect of ligand substitution on DNA binding ability of two new square planar copper(II)-Schiff base complexes

Dipali Sadhukhan; Aurkie Ray; Saurabh Das; Corrado Rizzoli; Georgina M. Rosair; Samiran Mitra

doi:10.1016/j.molstruc.2010.04.034

Effect of ligand substitution on DNA binding ability of two new square planar copper(II)-Schiff base complexes

Dipali Sadhukhan, Aurkie Ray, Saurabh Das, Corrado Rizzoli, Georgina M. Rosair, Samiran Mitra

School of Engineering & Physical Sciences

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Two terdentate NNO donor Schiff base ligands CH₃C(OH){double bond, long}CHC(CH₃){double bond, long}NCH₂C₅H₄N [HL¹] and C₆H₅C(OH){double bond, long}CHC(CH₃){double bond, long}NCH₂C₅H₄N [HL²] were used to synthesize two mononuclear square planar copper(II) complexes, [CuL¹(CF₃COO)] (1) and [CuL²(CF₃COO)] (2). The complexes were characterized by elemental analyses, FT-IR, UV-vis spectral methods and their structures were established by single crystal X-ray diffraction study. The biochemical activity of the complexes towards DNA binding were performed using absorbance and fluorescence titration methods and their mode of binding with calf thymus DNA has been established by viscosity measurement technique. © 2010 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	265-273
Number of pages	9
Journal	Journal of Molecular Structure
Volume	975
Issue number	1-3
DOIs	https://doi.org/10.1016/j.molstruc.2010.04.034
Publication status	Published - 30 Jun 2010

Keywords

Bifurcated H-bonding
Copper(II) complexes
CT-DNA
Hypochromism
Intercalation
Square planarity

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10.1016/j.molstruc.2010.04.034

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title = "Effect of ligand substitution on DNA binding ability of two new square planar copper(II)-Schiff base complexes",

abstract = "Two terdentate NNO donor Schiff base ligands CH3C(OH){double bond, long}CHC(CH3){double bond, long}NCH2C5H4N [HL1] and C6H5C(OH){double bond, long}CHC(CH3){double bond, long}NCH2C5H4N [HL2] were used to synthesize two mononuclear square planar copper(II) complexes, [CuL1(CF3COO)] (1) and [CuL2(CF3COO)] (2). The complexes were characterized by elemental analyses, FT-IR, UV-vis spectral methods and their structures were established by single crystal X-ray diffraction study. The biochemical activity of the complexes towards DNA binding were performed using absorbance and fluorescence titration methods and their mode of binding with calf thymus DNA has been established by viscosity measurement technique. {\textcopyright} 2010 Elsevier B.V. All rights reserved.",

keywords = "Bifurcated H-bonding, Copper(II) complexes, CT-DNA, Hypochromism, Intercalation, Square planarity",

author = "Dipali Sadhukhan and Aurkie Ray and Saurabh Das and Corrado Rizzoli and Rosair, {Georgina M.} and Samiran Mitra",

year = "2010",

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doi = "10.1016/j.molstruc.2010.04.034",

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pages = "265--273",

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T1 - Effect of ligand substitution on DNA binding ability of two new square planar copper(II)-Schiff base complexes

AU - Sadhukhan, Dipali

AU - Ray, Aurkie

AU - Das, Saurabh

AU - Rizzoli, Corrado

AU - Rosair, Georgina M.

AU - Mitra, Samiran

PY - 2010/6/30

Y1 - 2010/6/30

N2 - Two terdentate NNO donor Schiff base ligands CH3C(OH){double bond, long}CHC(CH3){double bond, long}NCH2C5H4N [HL1] and C6H5C(OH){double bond, long}CHC(CH3){double bond, long}NCH2C5H4N [HL2] were used to synthesize two mononuclear square planar copper(II) complexes, [CuL1(CF3COO)] (1) and [CuL2(CF3COO)] (2). The complexes were characterized by elemental analyses, FT-IR, UV-vis spectral methods and their structures were established by single crystal X-ray diffraction study. The biochemical activity of the complexes towards DNA binding were performed using absorbance and fluorescence titration methods and their mode of binding with calf thymus DNA has been established by viscosity measurement technique. © 2010 Elsevier B.V. All rights reserved.

AB - Two terdentate NNO donor Schiff base ligands CH3C(OH){double bond, long}CHC(CH3){double bond, long}NCH2C5H4N [HL1] and C6H5C(OH){double bond, long}CHC(CH3){double bond, long}NCH2C5H4N [HL2] were used to synthesize two mononuclear square planar copper(II) complexes, [CuL1(CF3COO)] (1) and [CuL2(CF3COO)] (2). The complexes were characterized by elemental analyses, FT-IR, UV-vis spectral methods and their structures were established by single crystal X-ray diffraction study. The biochemical activity of the complexes towards DNA binding were performed using absorbance and fluorescence titration methods and their mode of binding with calf thymus DNA has been established by viscosity measurement technique. © 2010 Elsevier B.V. All rights reserved.

KW - Bifurcated H-bonding

KW - Copper(II) complexes

KW - CT-DNA

KW - Hypochromism

KW - Intercalation

KW - Square planarity

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DO - 10.1016/j.molstruc.2010.04.034

M3 - Article

VL - 975

SP - 265

EP - 273

JO - Journal of Molecular Structure

JF - Journal of Molecular Structure

SN - 0022-2860

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