Effect of ligand substitution on DNA binding ability of two new square planar copper(II)-Schiff base complexes

Dipali Sadhukhan, Aurkie Ray, Saurabh Das, Corrado Rizzoli, Georgina M. Rosair, Samiran Mitra

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Two terdentate NNO donor Schiff base ligands CH3C(OH){double bond, long}CHC(CH3){double bond, long}NCH2C5H4N [HL1] and C6H5C(OH){double bond, long}CHC(CH3){double bond, long}NCH2C5H4N [HL2] were used to synthesize two mononuclear square planar copper(II) complexes, [CuL1(CF3COO)] (1) and [CuL2(CF3COO)] (2). The complexes were characterized by elemental analyses, FT-IR, UV-vis spectral methods and their structures were established by single crystal X-ray diffraction study. The biochemical activity of the complexes towards DNA binding were performed using absorbance and fluorescence titration methods and their mode of binding with calf thymus DNA has been established by viscosity measurement technique. © 2010 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)265-273
Number of pages9
JournalJournal of Molecular Structure
Volume975
Issue number1-3
DOIs
Publication statusPublished - 30 Jun 2010

Keywords

  • Bifurcated H-bonding
  • Copper(II) complexes
  • CT-DNA
  • Hypochromism
  • Intercalation
  • Square planarity

Fingerprint Dive into the research topics of 'Effect of ligand substitution on DNA binding ability of two new square planar copper(II)-Schiff base complexes'. Together they form a unique fingerprint.

  • Cite this