Premature infants are born with incompletely vascularised retinas and are at a risk of developing retinopathy of prematurity (ROP). Rate of prenatal and postnatal body growth is important in the pathogenesis of ROP. The aim of this study was to develop a physiology-based rat model in order to study the effect of growth restriction and oxygen on early retinal vascular development.
Dhaliwal, C. A., Wade, J., Gillespie, T., Aspinall, P., McIntosh, N., & Fleck, B. W. (2011). Early retinal blood vessel growth in normal and growth restricted rat pups raised in oxygen and room air. British Journal of Ophthalmology, 95(11), 1592-6. https://doi.org/10.1136/bjophthalmol-2011-300276