Dynamic Acoustic Field for Tuneable and Scalable Particle Sorting

G. D. Skotis; M.A.B. Andrade; S. Ritchie; D. R. S. Cumming; M. O. Riehle; Anne Bernassau

doi:10.1109/ULTSYM.2015.0022

Dynamic Acoustic Field for Tuneable and Scalable Particle Sorting

G. D. Skotis, M.A.B. Andrade, S. Ritchie, D. R. S. Cumming, M. O. Riehle, Anne Bernassau

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Abstract

Separation of cells is a critical process for studying cell properties, disease diagnostics, and therapeutics. Cell sorting by acoustic waves offers a means to separate cells on the basis of their size and physical properties in a label-free, contactless, and biocompatible manner. In this work, we introduce a unique technique, which use a dynamic acoustic field (DAF), based on the modulation of the phase of the standing wave. Using our dynamic acoustic field, we successfully separated 10 and 45 µm diameter polystyrene particles with a separation efficiency of 100%, and separated 6 and 10 µm polystyrene particles with an efficiency of ∼97%. We illustrate that DAF is capable of effectively separating dorsal root ganglion cells from heterogeneous medium. Finally, we demonstrate the scalability of the DAF method by sorting polystyrene particles of 5 mm and 2 mm diameter in air.

Original language	English
Pages	1-4
Number of pages	4
DOIs	https://doi.org/10.1109/ULTSYM.2015.0022
Publication status	Published - 2015
Event	IEEE International Ultrasonics Symposium 2015 - Taipei International Convention Center, Taipei, Taiwan, Province of China Duration: 21 Oct 2015 → 24 Oct 2015

Conference

Conference	IEEE International Ultrasonics Symposium 2015
Abbreviated title	IUS 2015
Country/Territory	Taiwan, Province of China
City	Taipei
Period	21/10/15 → 24/10/15

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10.1109/ULTSYM.2015.0022

IEEE IUS 2015_Final
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Cite this

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title = "Dynamic Acoustic Field for Tuneable and Scalable Particle Sorting",

abstract = "Separation of cells is a critical process for studying cell properties, disease diagnostics, and therapeutics. Cell sorting by acoustic waves offers a means to separate cells on the basis of their size and physical properties in a label-free, contactless, and biocompatible manner. In this work, we introduce a unique technique, which use a dynamic acoustic field (DAF), based on the modulation of the phase of the standing wave. Using our dynamic acoustic field, we successfully separated 10 and 45 µm diameter polystyrene particles with a separation efficiency of 100%, and separated 6 and 10 µm polystyrene particles with an efficiency of ∼97%. We illustrate that DAF is capable of effectively separating dorsal root ganglion cells from heterogeneous medium. Finally, we demonstrate the scalability of the DAF method by sorting polystyrene particles of 5 mm and 2 mm diameter in air.",

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doi = "10.1109/ULTSYM.2015.0022",

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AU - Skotis, G. D.

AU - Andrade, M.A.B.

AU - Ritchie, S.

AU - Cumming, D. R. S.

AU - Riehle, M. O.

AU - Bernassau, Anne

PY - 2015

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N2 - Separation of cells is a critical process for studying cell properties, disease diagnostics, and therapeutics. Cell sorting by acoustic waves offers a means to separate cells on the basis of their size and physical properties in a label-free, contactless, and biocompatible manner. In this work, we introduce a unique technique, which use a dynamic acoustic field (DAF), based on the modulation of the phase of the standing wave. Using our dynamic acoustic field, we successfully separated 10 and 45 µm diameter polystyrene particles with a separation efficiency of 100%, and separated 6 and 10 µm polystyrene particles with an efficiency of ∼97%. We illustrate that DAF is capable of effectively separating dorsal root ganglion cells from heterogeneous medium. Finally, we demonstrate the scalability of the DAF method by sorting polystyrene particles of 5 mm and 2 mm diameter in air.

AB - Separation of cells is a critical process for studying cell properties, disease diagnostics, and therapeutics. Cell sorting by acoustic waves offers a means to separate cells on the basis of their size and physical properties in a label-free, contactless, and biocompatible manner. In this work, we introduce a unique technique, which use a dynamic acoustic field (DAF), based on the modulation of the phase of the standing wave. Using our dynamic acoustic field, we successfully separated 10 and 45 µm diameter polystyrene particles with a separation efficiency of 100%, and separated 6 and 10 µm polystyrene particles with an efficiency of ∼97%. We illustrate that DAF is capable of effectively separating dorsal root ganglion cells from heterogeneous medium. Finally, we demonstrate the scalability of the DAF method by sorting polystyrene particles of 5 mm and 2 mm diameter in air.

U2 - 10.1109/ULTSYM.2015.0022

DO - 10.1109/ULTSYM.2015.0022

M3 - Paper

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EP - 4

T2 - IEEE International Ultrasonics Symposium 2015

Y2 - 21 October 2015 through 24 October 2015

ER -

Dynamic Acoustic Field for Tuneable and Scalable Particle Sorting

Abstract

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