Dual Task Abilities in Alzheimer's Disease due to E280A Single Presenilin-1 Mutation

Sarah E. MacPherson, Mario Parra Rodriguez, Sonia Moreno, Francisco Lopera, Sergio Della Sala

    Research output: Contribution to conferenceOther

    Abstract

    Objective: Our previous work has demonstrated that patients with sporadic
    Alzheimer?s disease (AD) are impaired in their ability to perform
    two tasks simultaneously compared to healthy controls, despite being
    able to successfully perform the tasks alone relatively well. Yet, it remains
    unclear what the earliest clinical manifestation of this dual task
    coordination deficit is. In this talk, our recent work examining dual
    task abilities in individuals who are at risk of early-onset familial AD
    due to an E280A presenilin-1 mutation will be discussed. The aim was
    to investigate whether the dual task paradigm can differentiate between
    those asymptomatic family members who test positive for the gene mutation
    and family members who test negative for the gene mutation.
    Participants and Methods: Twelve patients with mild AD, 25 asymptomatic
    carriers and 33 non-carriers of the gene mutation were asked
    to perform digit recall accompanied by a secondary tracking task.
    Results: Despite performing well on a variety of neuropsychological
    measures, including episodic memory tasks, the asymptomatic carriers
    show dual task decrements compared to those family members without
    the gene mutation.
    Original languageEnglish
    Pages28-29
    Number of pages2
    Publication statusPublished - Jul 2009

    Fingerprint

    Presenilin-1
    Aptitude
    Alzheimer Disease
    Mutation
    Genes
    Episodic Memory

    Cite this

    MacPherson, S. E., Parra Rodriguez, M., Moreno, S., Lopera, F., & Della Sala, S. (2009). Dual Task Abilities in Alzheimer's Disease due to E280A Single Presenilin-1 Mutation. 28-29.
    MacPherson, Sarah E. ; Parra Rodriguez, Mario ; Moreno, Sonia ; Lopera, Francisco ; Della Sala, Sergio. / Dual Task Abilities in Alzheimer's Disease due to E280A Single Presenilin-1 Mutation. 2 p.
    @conference{de6c4ce3df8c45568210071f82209578,
    title = "Dual Task Abilities in Alzheimer's Disease due to E280A Single Presenilin-1 Mutation",
    abstract = "Objective: Our previous work has demonstrated that patients with sporadicAlzheimer?s disease (AD) are impaired in their ability to performtwo tasks simultaneously compared to healthy controls, despite beingable to successfully perform the tasks alone relatively well. Yet, it remainsunclear what the earliest clinical manifestation of this dual taskcoordination deficit is. In this talk, our recent work examining dualtask abilities in individuals who are at risk of early-onset familial ADdue to an E280A presenilin-1 mutation will be discussed. The aim wasto investigate whether the dual task paradigm can differentiate betweenthose asymptomatic family members who test positive for the gene mutationand family members who test negative for the gene mutation.Participants and Methods: Twelve patients with mild AD, 25 asymptomaticcarriers and 33 non-carriers of the gene mutation were askedto perform digit recall accompanied by a secondary tracking task.Results: Despite performing well on a variety of neuropsychologicalmeasures, including episodic memory tasks, the asymptomatic carriersshow dual task decrements compared to those family members withoutthe gene mutation.",
    author = "MacPherson, {Sarah E.} and {Parra Rodriguez}, Mario and Sonia Moreno and Francisco Lopera and {Della Sala}, Sergio",
    year = "2009",
    month = "7",
    language = "English",
    pages = "28--29",

    }

    MacPherson, SE, Parra Rodriguez, M, Moreno, S, Lopera, F & Della Sala, S 2009, 'Dual Task Abilities in Alzheimer's Disease due to E280A Single Presenilin-1 Mutation' pp. 28-29.

    Dual Task Abilities in Alzheimer's Disease due to E280A Single Presenilin-1 Mutation. / MacPherson, Sarah E.; Parra Rodriguez, Mario; Moreno, Sonia; Lopera, Francisco; Della Sala, Sergio.

    2009. 28-29.

    Research output: Contribution to conferenceOther

    TY - CONF

    T1 - Dual Task Abilities in Alzheimer's Disease due to E280A Single Presenilin-1 Mutation

    AU - MacPherson, Sarah E.

    AU - Parra Rodriguez, Mario

    AU - Moreno, Sonia

    AU - Lopera, Francisco

    AU - Della Sala, Sergio

    PY - 2009/7

    Y1 - 2009/7

    N2 - Objective: Our previous work has demonstrated that patients with sporadicAlzheimer?s disease (AD) are impaired in their ability to performtwo tasks simultaneously compared to healthy controls, despite beingable to successfully perform the tasks alone relatively well. Yet, it remainsunclear what the earliest clinical manifestation of this dual taskcoordination deficit is. In this talk, our recent work examining dualtask abilities in individuals who are at risk of early-onset familial ADdue to an E280A presenilin-1 mutation will be discussed. The aim wasto investigate whether the dual task paradigm can differentiate betweenthose asymptomatic family members who test positive for the gene mutationand family members who test negative for the gene mutation.Participants and Methods: Twelve patients with mild AD, 25 asymptomaticcarriers and 33 non-carriers of the gene mutation were askedto perform digit recall accompanied by a secondary tracking task.Results: Despite performing well on a variety of neuropsychologicalmeasures, including episodic memory tasks, the asymptomatic carriersshow dual task decrements compared to those family members withoutthe gene mutation.

    AB - Objective: Our previous work has demonstrated that patients with sporadicAlzheimer?s disease (AD) are impaired in their ability to performtwo tasks simultaneously compared to healthy controls, despite beingable to successfully perform the tasks alone relatively well. Yet, it remainsunclear what the earliest clinical manifestation of this dual taskcoordination deficit is. In this talk, our recent work examining dualtask abilities in individuals who are at risk of early-onset familial ADdue to an E280A presenilin-1 mutation will be discussed. The aim wasto investigate whether the dual task paradigm can differentiate betweenthose asymptomatic family members who test positive for the gene mutationand family members who test negative for the gene mutation.Participants and Methods: Twelve patients with mild AD, 25 asymptomaticcarriers and 33 non-carriers of the gene mutation were askedto perform digit recall accompanied by a secondary tracking task.Results: Despite performing well on a variety of neuropsychologicalmeasures, including episodic memory tasks, the asymptomatic carriersshow dual task decrements compared to those family members withoutthe gene mutation.

    M3 - Other

    SP - 28

    EP - 29

    ER -

    MacPherson SE, Parra Rodriguez M, Moreno S, Lopera F, Della Sala S. Dual Task Abilities in Alzheimer's Disease due to E280A Single Presenilin-1 Mutation. 2009.