Dual Targeting of Function-Structure for Effective Killing of Pathogenic Free-Living Amoebae

R. Siddiqui; M. Y. Abouleish; M. Khamis; T. Ibrahim; N. A. Khan

doi:10.1021/acsmedchemlett.1c00200

Dual Targeting of Function-Structure for Effective Killing of Pathogenic Free-Living Amoebae

R. Siddiqui, M. Y. Abouleish, M. Khamis, T. Ibrahim, N. A. Khan

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Here we discuss the potential value of targeting both the hardy structure of the cyst state of the parasite, in addition to the active trophozoite form, to provide target-directed inhibition as a viable drug strategy in the effective eradication of parasites.

Original language	English
Pages (from-to)	672−676
Number of pages	5
Journal	ACS Medicinal Chemistry Letters
Volume	12
Issue number	5
Early online date	30 Apr 2021
DOIs	https://doi.org/10.1021/acsmedchemlett.1c00200
Publication status	Published - 13 May 2021

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title = "Dual Targeting of Function-Structure for Effective Killing of Pathogenic Free-Living Amoebae",

abstract = "Here we discuss the potential value of targeting both the hardy structure of the cyst state of the parasite, in addition to the active trophozoite form, to provide target-directed inhibition as a viable drug strategy in the effective eradication of parasites.",

author = "R. Siddiqui and Abouleish, \{M. Y.\} and M. Khamis and T. Ibrahim and Khan, \{N. A.\}",

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AU - Siddiqui, R.

AU - Abouleish, M. Y.

AU - Khamis, M.

AU - Ibrahim, T.

AU - Khan, N. A.

PY - 2021/5/13

Y1 - 2021/5/13

N2 - Here we discuss the potential value of targeting both the hardy structure of the cyst state of the parasite, in addition to the active trophozoite form, to provide target-directed inhibition as a viable drug strategy in the effective eradication of parasites.

AB - Here we discuss the potential value of targeting both the hardy structure of the cyst state of the parasite, in addition to the active trophozoite form, to provide target-directed inhibition as a viable drug strategy in the effective eradication of parasites.

UR - https://www.scopus.com/pages/publications/85106419389

U2 - 10.1021/acsmedchemlett.1c00200

DO - 10.1021/acsmedchemlett.1c00200

M3 - Article

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SN - 1948-5875

VL - 12

SP - 672−676

JO - ACS Medicinal Chemistry Letters

JF - ACS Medicinal Chemistry Letters

IS - 5

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Dual Targeting of Function-Structure for Effective Killing of Pathogenic Free-Living Amoebae

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