Droplet control technologies for microfluidic high throughput screening (μHTS)

Muhsincan Sesen, Tuncay Alan, Adrian Neild

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)
176 Downloads (Pure)

Abstract

The transition from micro well plate and robotics based high throughput screening (HTS) to chip based screening has already started. This transition promises reduced droplet volumes thereby decreasing the amount of ?uids used in these studies. Moreover, it signi?cantly boosts throughput allowing screening to keep pace with the overwhelming number of molecular targets being discovered. In this review, we analyse state-of-the-art droplet control technologies that exhibit potential to be used in this new generation of screening devices. Since these systems are enclosed and usually planar, even some of the straightforward methods used in traditional HTS such as pipetting and reading can prove challenging to replicate in Micro?uidic High Throughput Screening ([small micro]HTS). We critically review the technologies developed for this purpose in depth, describing the underlying physics and discussing the future outlooks.
Original languageEnglish
JournalLab on a Chip
Early online date9 Jun 2017
DOIs
Publication statusE-pub ahead of print - 9 Jun 2017

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