Abstract
The relationships between the inhaled dose of foot and mouth disease virus and the outcomes of infection and disease were examined by fitting dose-response models to experimental data. The parameters for both the exponential and beta-poisson models were estimated using maximum likelihood and Bayesian methods. The median probability of infection given a single inhaled TCID50 was estimated to be 0.031 with 95% Bayesian credibility intervals (CI) of 0.018-0.052 for cattle, and 0.045 (CI = 0.024-0.080) for sheep. These estimates were used to construct dose-response curves and uncertainty distributions for use in quantitative risk assessments.
Original language | English |
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Article number | 12002551 |
Pages (from-to) | 325-332 |
Number of pages | 8 |
Journal | Epidemiology and Infection |
Volume | 128 |
Issue number | 2 |
DOIs | |
Publication status | Published - Apr 2002 |