Dose-response relationships for foot and mouth disease in cattle and sheep

Nigel P. French, Louise Kelly, R. Jones, Damian Clancy

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)


The relationships between the inhaled dose of foot and mouth disease virus and the outcomes of infection and disease were examined by fitting dose-response models to experimental data. The parameters for both the exponential and beta-poisson models were estimated using maximum likelihood and Bayesian methods. The median probability of infection given a single inhaled TCID50 was estimated to be 0.031 with 95% Bayesian credibility intervals (CI) of 0.018-0.052 for cattle, and 0.045 (CI = 0.024-0.080) for sheep. These estimates were used to construct dose-response curves and uncertainty distributions for use in quantitative risk assessments.
Original languageEnglish
Article number12002551
Pages (from-to)325-332
Number of pages8
JournalEpidemiology and Infection
Issue number2
Publication statusPublished - Apr 2002


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