Dose-response relationships for foot and mouth disease in cattle and sheep

Nigel P. French, Louise Kelly, R. Jones, Damian Clancy

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The relationships between the inhaled dose of foot and mouth disease virus and the outcomes of infection and disease were examined by fitting dose-response models to experimental data. The parameters for both the exponential and beta-poisson models were estimated using maximum likelihood and Bayesian methods. The median probability of infection given a single inhaled TCID50 was estimated to be 0.031 with 95% Bayesian credibility intervals (CI) of 0.018-0.052 for cattle, and 0.045 (CI = 0.024-0.080) for sheep. These estimates were used to construct dose-response curves and uncertainty distributions for use in quantitative risk assessments.
Original languageEnglish
Article number12002551
Pages (from-to)325-332
Number of pages8
JournalEpidemiology and Infection
Volume128
Issue number2
DOIs
Publication statusPublished - Apr 2002

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