DNA damage and autophagy

Humberto Rodriguez-Rocha, Aracely Garcia-Garcia, Mihalis I Panayiotidis, Rodrigo Franco

    Research output: Contribution to journalLiterature review

    126 Citations (Scopus)

    Abstract

    Both exogenous and endogenous agents are a threat to DNA integrity. Exogenous environmental agents such as ultraviolet (UV) and ionizing radiation, genotoxic chemicals and endogenous byproducts of metabolism including reactive oxygen species can cause alterations in DNA structure (DNA damage). Unrepaired DNA damage has been linked to a variety of human disorders including cancer and neurodegenerative disease. Thus, efficient mechanisms to detect DNA lesions, signal their presence and promote their repair have been evolved in cells. If DNA is effectively repaired, DNA damage response is inactivated and normal cell functioning resumes. In contrast, when DNA lesions cannot be removed, chronic DNA damage triggers specific cell responses such as cell death and senescence. Recently, DNA damage has been shown to induce autophagy, a cellular catabolic process that maintains a balance between synthesis, degradation, and recycling of cellular components. But the exact mechanisms by which DNA damage triggers autophagy are unclear. More importantly, the role of autophagy in the DNA damage response and cellular fate is unknown. In this review we analyze evidence that supports a role for autophagy as an integral part of the DNA damage response.
    Original languageEnglish
    Pages (from-to)158-166
    Number of pages9
    JournalMutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
    Volume711
    Issue number1-2
    DOIs
    Publication statusPublished - 3 Jun 2011

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  • Cite this

    Rodriguez-Rocha, H., Garcia-Garcia, A., Panayiotidis, M. I., & Franco, R. (2011). DNA damage and autophagy. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 711(1-2), 158-166. https://doi.org/10.1016/j.mrfmmm.2011.03.007