Discovery of Novel Materials with Broad Resistance to Bacterial Attachment Using Combinatorial Polymer Microarrays

Andrew L. Hook; Chien-Yi Chang; Jing Yang; Steve Atkinson; Robert Langer; Daniel G. Anderson; Martyn C. Davies; Paul Williams; Morgan R. Alexander

doi:10.1002/adma.201204936

Discovery of Novel Materials with Broad Resistance to Bacterial Attachment Using Combinatorial Polymer Microarrays

Andrew L. Hook, Chien-Yi Chang, Jing Yang, Steve Atkinson, Robert Langer, Daniel G. Anderson, Martyn C. Davies, Paul Williams, Morgan R. Alexander^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

94 Citations (Scopus)

Abstract

A new class of bacteria-attachment-resistant materials is discovered using a multi-generation polymer microarray methodology that reduces bacterial attachment by up to 99.3% compared with a leading commercially available silver hydrogel anti-bacterial material. The coverage of three bacterial species, Pseudomonas aeruginosa, Staphylococcus aureus, and uropathogenic Escherichia coli is assessed.

Original language	English
Pages (from-to)	2542-2547
Number of pages	6
Journal	Advanced Materials
Volume	25
Issue number	18
DOIs	https://doi.org/10.1002/adma.201204936
Publication status	Published - 14 May 2013

Keywords

anti-fouling
bacteria
biofilms
high throughput
microarrays

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.201204936

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title = "Discovery of Novel Materials with Broad Resistance to Bacterial Attachment Using Combinatorial Polymer Microarrays",

abstract = "A new class of bacteria-attachment-resistant materials is discovered using a multi-generation polymer microarray methodology that reduces bacterial attachment by up to 99.3\% compared with a leading commercially available silver hydrogel anti-bacterial material. The coverage of three bacterial species, Pseudomonas aeruginosa, Staphylococcus aureus, and uropathogenic Escherichia coli is assessed.",

keywords = "anti-fouling, bacteria, biofilms, high throughput, microarrays",

author = "Hook, \{Andrew L.\} and Chien-Yi Chang and Jing Yang and Steve Atkinson and Robert Langer and Anderson, \{Daniel G.\} and Davies, \{Martyn C.\} and Paul Williams and Alexander, \{Morgan R.\}",

year = "2013",

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doi = "10.1002/adma.201204936",

language = "English",

volume = "25",

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journal = "Advanced Materials",

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AU - Hook, Andrew L.

AU - Chang, Chien-Yi

AU - Yang, Jing

AU - Atkinson, Steve

AU - Langer, Robert

AU - Anderson, Daniel G.

AU - Davies, Martyn C.

AU - Williams, Paul

AU - Alexander, Morgan R.

PY - 2013/5/14

Y1 - 2013/5/14

N2 - A new class of bacteria-attachment-resistant materials is discovered using a multi-generation polymer microarray methodology that reduces bacterial attachment by up to 99.3% compared with a leading commercially available silver hydrogel anti-bacterial material. The coverage of three bacterial species, Pseudomonas aeruginosa, Staphylococcus aureus, and uropathogenic Escherichia coli is assessed.

AB - A new class of bacteria-attachment-resistant materials is discovered using a multi-generation polymer microarray methodology that reduces bacterial attachment by up to 99.3% compared with a leading commercially available silver hydrogel anti-bacterial material. The coverage of three bacterial species, Pseudomonas aeruginosa, Staphylococcus aureus, and uropathogenic Escherichia coli is assessed.

KW - anti-fouling

KW - bacteria

KW - biofilms

KW - high throughput

KW - microarrays

UR - https://www.scopus.com/pages/publications/84877252040

U2 - 10.1002/adma.201204936

DO - 10.1002/adma.201204936

M3 - Article

C2 - 23417823

AN - SCOPUS:84877252040

SN - 0935-9648

VL - 25

SP - 2542

EP - 2547

JO - Advanced Materials

JF - Advanced Materials

IS - 18

ER -

Discovery of Novel Materials with Broad Resistance to Bacterial Attachment Using Combinatorial Polymer Microarrays

Abstract

Keywords

ASJC Scopus subject areas

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