Discovery of Novel Materials with Broad Resistance to Bacterial Attachment Using Combinatorial Polymer Microarrays

Andrew L. Hook; Chien-Yi Chang; Jing Yang; Steve Atkinson; Robert Langer; Daniel G. Anderson; Martyn C. Davies; Paul Williams; Morgan R. Alexander

doi:10.1002/adma.201204936

Discovery of Novel Materials with Broad Resistance to Bacterial Attachment Using Combinatorial Polymer Microarrays

Andrew L. Hook, Chien-Yi Chang, Jing Yang, Steve Atkinson, Robert Langer, Daniel G. Anderson, Martyn C. Davies, Paul Williams, Morgan R. Alexander^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

88 Citations (Scopus)

Abstract

A new class of bacteria-attachment-resistant materials is discovered using a multi-generation polymer microarray methodology that reduces bacterial attachment by up to 99.3% compared with a leading commercially available silver hydrogel anti-bacterial material. The coverage of three bacterial species, Pseudomonas aeruginosa, Staphylococcus aureus, and uropathogenic Escherichia coli is assessed.

Original language	English
Pages (from-to)	2542-2547
Number of pages	6
Journal	Advanced Materials
Volume	25
Issue number	18
DOIs	https://doi.org/10.1002/adma.201204936
Publication status	Published - 14 May 2013

Keywords

anti-fouling
bacteria
biofilms
high throughput
microarrays

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

Access to Document

10.1002/adma.201204936

Cite this

@article{e9344aa06e044230b344c93eb33f72b1,

title = "Discovery of Novel Materials with Broad Resistance to Bacterial Attachment Using Combinatorial Polymer Microarrays",

abstract = "A new class of bacteria-attachment-resistant materials is discovered using a multi-generation polymer microarray methodology that reduces bacterial attachment by up to 99.3% compared with a leading commercially available silver hydrogel anti-bacterial material. The coverage of three bacterial species, Pseudomonas aeruginosa, Staphylococcus aureus, and uropathogenic Escherichia coli is assessed.",

keywords = "anti-fouling, bacteria, biofilms, high throughput, microarrays",

author = "Hook, {Andrew L.} and Chien-Yi Chang and Jing Yang and Steve Atkinson and Robert Langer and Anderson, {Daniel G.} and Davies, {Martyn C.} and Paul Williams and Alexander, {Morgan R.}",

year = "2013",

month = may,

day = "14",

doi = "10.1002/adma.201204936",

language = "English",

volume = "25",

pages = "2542--2547",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley-VCH Verlag",

number = "18",

}

TY - JOUR

T1 - Discovery of Novel Materials with Broad Resistance to Bacterial Attachment Using Combinatorial Polymer Microarrays

AU - Hook, Andrew L.

AU - Chang, Chien-Yi

AU - Yang, Jing

AU - Atkinson, Steve

AU - Langer, Robert

AU - Anderson, Daniel G.

AU - Davies, Martyn C.

AU - Williams, Paul

AU - Alexander, Morgan R.

PY - 2013/5/14

Y1 - 2013/5/14

N2 - A new class of bacteria-attachment-resistant materials is discovered using a multi-generation polymer microarray methodology that reduces bacterial attachment by up to 99.3% compared with a leading commercially available silver hydrogel anti-bacterial material. The coverage of three bacterial species, Pseudomonas aeruginosa, Staphylococcus aureus, and uropathogenic Escherichia coli is assessed.

AB - A new class of bacteria-attachment-resistant materials is discovered using a multi-generation polymer microarray methodology that reduces bacterial attachment by up to 99.3% compared with a leading commercially available silver hydrogel anti-bacterial material. The coverage of three bacterial species, Pseudomonas aeruginosa, Staphylococcus aureus, and uropathogenic Escherichia coli is assessed.

KW - anti-fouling

KW - bacteria

KW - biofilms

KW - high throughput

KW - microarrays

UR - http://www.scopus.com/inward/record.url?scp=84877252040&partnerID=8YFLogxK

U2 - 10.1002/adma.201204936

DO - 10.1002/adma.201204936

M3 - Article

C2 - 23417823

AN - SCOPUS:84877252040

SN - 0935-9648

VL - 25

SP - 2542

EP - 2547

JO - Advanced Materials

JF - Advanced Materials

IS - 18

ER -

Discovery of Novel Materials with Broad Resistance to Bacterial Attachment Using Combinatorial Polymer Microarrays

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this