Direct Hydrodecarboxylation of Aliphatic Carboxylic Acids: Metal- and Light-Free

Euan B. McLean; David T. Mooney; David J. Burns; Ai-Lan Lee

doi:10.1021/acs.orglett.1c04079

Direct Hydrodecarboxylation of Aliphatic Carboxylic Acids: Metal- and Light-Free

Euan B. McLean, David T. Mooney, David J. Burns, Ai-Lan Lee

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

150 Downloads (Pure)

Abstract

A mild and inexpensive method for direct hydrodecarboxylation of aliphatic carboxylic acids has been developed. The reaction does not require metals, light, or catalysts, rendering the protocol operationally simple, easy to scale, and more sustainable. Crucially, no additional H atom source is required in most cases, while a broad substrate scope and functional group tolerance are observed.

Original language	English
Pages (from-to)	686-691
Number of pages	6
Journal	Organic letters
Volume	24
Issue number	2
Early online date	7 Jan 2022
DOIs	https://doi.org/10.1021/acs.orglett.1c04079
Publication status	Published - 21 Jan 2022

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "A mild and inexpensive method for direct hydrodecarboxylation of aliphatic carboxylic acids has been developed. The reaction does not require metals, light, or catalysts, rendering the protocol operationally simple, easy to scale, and more sustainable. Crucially, no additional H atom source is required in most cases, while a broad substrate scope and functional group tolerance are observed.",

author = "McLean, {Euan B.} and Mooney, {David T.} and Burns, {David J.} and Ai-Lan Lee",

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AU - Burns, David J.

AU - Lee, Ai-Lan

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Direct Hydrodecarboxylation of Aliphatic Carboxylic Acids: Metal- and Light-Free

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