Direct Hydrodecarboxylation of Aliphatic Carboxylic Acids: Metal- and Light-Free

Euan B. McLean, David T. Mooney, David J. Burns, Ai-Lan Lee

Research output: Contribution to journalArticlepeer-review

Abstract

A mild and inexpensive method for direct hydrodecarboxylation of aliphatic carboxylic acids has been developed. The reaction does not require metals, light, or catalysts, rendering the protocol operationally simple, easy to scale, and more sustainable. Crucially, no additional H atom source is required in most cases, while a broad substrate scope and functional group tolerance are observed.

Original languageEnglish
JournalOrganic letters
Early online date7 Jan 2022
DOIs
Publication statusE-pub ahead of print - 7 Jan 2022

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