Direct Hydrodecarboxylation of Aliphatic Carboxylic Acids: Metal- and Light-Free

Euan B. McLean, David T. Mooney, David J. Burns, Ai-Lan Lee

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)
125 Downloads (Pure)


A mild and inexpensive method for direct hydrodecarboxylation of aliphatic carboxylic acids has been developed. The reaction does not require metals, light, or catalysts, rendering the protocol operationally simple, easy to scale, and more sustainable. Crucially, no additional H atom source is required in most cases, while a broad substrate scope and functional group tolerance are observed.

Original languageEnglish
Pages (from-to)686-691
Number of pages6
JournalOrganic letters
Issue number2
Early online date7 Jan 2022
Publication statusPublished - 21 Jan 2022

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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