Direct decarboxylative Giese amidations: photocatalytic vs. metal- and light-free

David M. Kitcatt, Katie A. Scott, Elena Rongione, Simon Nicolle, Ai-Lan Lee*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A direct intermolecular decarboxylative Giese amidation reaction from bench stable, non-toxic and environmentally benign oxamic acids has been developed, which allows for easy access to 1,4-difunctionalised compounds which are not otherwise readily accessible. Crucially, a more general acceptor substrate scope is now possible, which renders the Giese amidation applicable to more complex substrates such as natural products and chiral building blocks. Two different photocatalytic methods (one via oxidative and the other via reductive quenching cycles) and one metal- and light-free method were developed and the flexibility provided by different conditions proved to be crucial for enabling a more general substrate scope.
Original languageEnglish
Pages (from-to)9806-9813
Number of pages8
JournalChemical Science
Issue number36
Early online date24 Aug 2023
Publication statusPublished - 28 Sept 2023

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