Direct C–H amidation of 1,3-azoles: light-mediated, photosensitiser-free vs. thermal †

David T. Mooney, Heather McKee, Tabea S. Batch, Samuel Drane, Peter R. Moore, Ai-Lan Lee*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
3 Downloads (Pure)

Abstract

We have developed one thermal and one light-mediated method for direct Minisci-type C–H amidation of 1,3-azoles, which are applicable to thiazoles, benzothiazoles, benzimidazoles, and for the first time, imidazoles. The new visible light-mediated approach can be rendered photosensitiser/photocatalyst-free and likely proceeds via an electron donor–acceptor (EDA) complex, the first direct Minisci-type amidation to do so.
Original languageEnglish
Pages (from-to)10752-10755
Number of pages4
JournalChemical Communications
Volume60
Issue number77
Early online date19 Aug 2024
DOIs
Publication statusPublished - 4 Oct 2024

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