Direct C-H Functionalization of Phenanthrolines: Metal- and Light-Free Dicarbamoylations

David T. Mooney, Benjamin D. T. Donkin, Nemrud Demirel, Peter R. Moore, Ai-Lan Lee

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
25 Downloads (Pure)


A direct method for C-H dicarbamoylations of phenanthrolines has been developed, which is capable of directly installing primary, secondary as well as tertiary amides. This is a significant improvement on the previous direct method, which was limited to primary amides. The metal-, light-, and catalyst-free Minisci-type reaction is cheap, operationally simple, and scalable. We demonstrate that the step efficiency toward dicarbamoylated phenanthroline targets can now be significantly improved.

Original languageEnglish
Pages (from-to)17282-17293
Number of pages12
JournalJournal of Organic Chemistry
Issue number23
Early online date18 Nov 2021
Publication statusPublished - 3 Dec 2021

ASJC Scopus subject areas

  • Organic Chemistry


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