Diastereoselective conjugate addition of ammonia in the synthesis of chiral pyrrolidines

Inmaculada Robina, R. Patrick Gearing, J. Grant Buchanan, Richard H. Wightman

Research output: Contribution to journalArticle

Abstract

threo-Selectivity in the conjugate addition of ammonia to 4,5-isopropylidenedioxypent-2-enoic esters has been exploited in a new synthesis of homochiral pyrrolidines; the origin of the diastereoselectivity is discussed.

Original languageEnglish
Pages (from-to)2622-2624
Number of pages3
JournalJournal of the Chemical Society, Perkin Transactions 1
Issue number9
Publication statusPublished - 1990

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