Development of anti-acanthamoebic approaches

Mohammad Ridwane Mungroo; Tommy Tong; Naveed Ahmed Khan; Tengku Shahrul Anuar; Sutherland Kester Maciver; Ruqaiyyah Siddiqui

doi:10.1007/s10123-021-00171-3

Development of anti-acanthamoebic approaches

Mohammad Ridwane Mungroo, Tommy Tong, Naveed Ahmed Khan, Tengku Shahrul Anuar, Sutherland Kester Maciver, Ruqaiyyah Siddiqui

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Acanthamoeba keratitis is a sight-endangering eye infection, and causative organism Acanthamoeba presents a significant concern to public health, given escalation of contact lens wearers. Contemporary therapy is burdensome, necessitating prompt diagnosis and aggressive treatment. None of the contact lens disinfectants (local and international) can eradicate Acanthamoeba effectively. Using a range of compounds targeting cellulose, ion channels, and biochemical pathways, we employed bioassay-guided testing to determine their anti-amoebic effects. The results indicated that acarbose, indaziflam, terbuthylazine, glimepiride, inositol, vildagliptin and repaglinide showed anti-amoebic effects. Compounds showed minimal toxicity on human cells. Therefore, effects of the evaluated compounds after conjugation with nanoparticles should certainly be the subject of future studies and will likely lead to promising leads for potential applications.

Original language	English
Pages (from-to)	363–371
Number of pages	9
Journal	International Microbiology
Volume	24
Issue number	3
Early online date	23 Mar 2021
DOIs	https://doi.org/10.1007/s10123-021-00171-3
Publication status	Published - Aug 2021

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title = "Development of anti-acanthamoebic approaches",

abstract = "Acanthamoeba keratitis is a sight-endangering eye infection, and causative organism Acanthamoeba presents a significant concern to public health, given escalation of contact lens wearers. Contemporary therapy is burdensome, necessitating prompt diagnosis and aggressive treatment. None of the contact lens disinfectants (local and international) can eradicate Acanthamoeba effectively. Using a range of compounds targeting cellulose, ion channels, and biochemical pathways, we employed bioassay-guided testing to determine their anti-amoebic effects. The results indicated that acarbose, indaziflam, terbuthylazine, glimepiride, inositol, vildagliptin and repaglinide showed anti-amoebic effects. Compounds showed minimal toxicity on human cells. Therefore, effects of the evaluated compounds after conjugation with nanoparticles should certainly be the subject of future studies and will likely lead to promising leads for potential applications.",

author = "Mungroo, {Mohammad Ridwane} and Tommy Tong and Khan, {Naveed Ahmed} and Anuar, {Tengku Shahrul} and Maciver, {Sutherland Kester} and Ruqaiyyah Siddiqui",

year = "2021",

month = aug,

doi = "10.1007/s10123-021-00171-3",

language = "English",

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journal = "International Microbiology",

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T1 - Development of anti-acanthamoebic approaches

AU - Mungroo, Mohammad Ridwane

AU - Tong, Tommy

AU - Khan, Naveed Ahmed

AU - Anuar, Tengku Shahrul

AU - Maciver, Sutherland Kester

AU - Siddiqui, Ruqaiyyah

PY - 2021/8

Y1 - 2021/8

N2 - Acanthamoeba keratitis is a sight-endangering eye infection, and causative organism Acanthamoeba presents a significant concern to public health, given escalation of contact lens wearers. Contemporary therapy is burdensome, necessitating prompt diagnosis and aggressive treatment. None of the contact lens disinfectants (local and international) can eradicate Acanthamoeba effectively. Using a range of compounds targeting cellulose, ion channels, and biochemical pathways, we employed bioassay-guided testing to determine their anti-amoebic effects. The results indicated that acarbose, indaziflam, terbuthylazine, glimepiride, inositol, vildagliptin and repaglinide showed anti-amoebic effects. Compounds showed minimal toxicity on human cells. Therefore, effects of the evaluated compounds after conjugation with nanoparticles should certainly be the subject of future studies and will likely lead to promising leads for potential applications.

AB - Acanthamoeba keratitis is a sight-endangering eye infection, and causative organism Acanthamoeba presents a significant concern to public health, given escalation of contact lens wearers. Contemporary therapy is burdensome, necessitating prompt diagnosis and aggressive treatment. None of the contact lens disinfectants (local and international) can eradicate Acanthamoeba effectively. Using a range of compounds targeting cellulose, ion channels, and biochemical pathways, we employed bioassay-guided testing to determine their anti-amoebic effects. The results indicated that acarbose, indaziflam, terbuthylazine, glimepiride, inositol, vildagliptin and repaglinide showed anti-amoebic effects. Compounds showed minimal toxicity on human cells. Therefore, effects of the evaluated compounds after conjugation with nanoparticles should certainly be the subject of future studies and will likely lead to promising leads for potential applications.

U2 - 10.1007/s10123-021-00171-3

DO - 10.1007/s10123-021-00171-3

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VL - 24

SP - 363

EP - 371

JO - International Microbiology

JF - International Microbiology

IS - 3

ER -

Development of anti-acanthamoebic approaches

Abstract

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