Detection of Cryptosporidium in miniaturised fluidic devices

Helen Bridle, Maiwenn Kersaudy-Kerhoas, Brian Miller, Despoina Gavriilidou, Frank Katzer, Elisabeth A. Innes, Marc P. Y. Desmulliez

Research output: Contribution to journalLiterature review

38 Citations (Scopus)
513 Downloads (Pure)

Abstract

Contamination of drinking water with the protozoan pathogen, Cryptosporidium, represents a serious risk to human health due to the low infectious dose and the resistance of this parasite to chlorine disinfection. Therefore, several countries have legislated for the frequent monitoring of drinking water for Cryptosporidium presence. Existing approved monitoring protocols are however time-consuming and do not provide essential information on the species, virulence or viability of detected oocysts. Rapid, more information-rich and automatable systems for Cryptosporidium detection are highly sought-after, and numerous miniaturised devices have been developed to address this need. This review article aims to summarise the state-of-the-art and compare the performance of these systems in terms of detection limit, ability to determine species, viability and performance in the presence of interferents. Finally, conclusions are drawn with regard to the most promising methods and directions of future research. (C) 2012 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)1641-1661
Number of pages21
JournalWater Research
Volume46
Issue number6
DOIs
Publication statusPublished - 15 Apr 2012

Keywords

  • Parasite
  • Cryptosporidium
  • Detection
  • Miniaturisation
  • Microfluidics

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