Designed multifunctional nanocomposites for biomedical applications

Humphrey Hak Ping Yiu, Hong-jun Niu, Ellen Biermans, Gustaaf van Tendeloo, Matthew J. Rosseinsky

Research output: Contribution to journalArticle

Abstract

The assembly of multifunctional nanocomposite materials is demonstrated by exploiting the molecular sieving property of SBA-16 nanoporous silica and using it as a template material. The cages of the pore networks are used to host iron oxide magnetic nanoparticles, leaving a pore volume of 0.29 cm(3) g(-1) accessible for drug storage. This iron oxide silica nanocomposite is then functionalized with amine groups. Finally the outside of the particle is decorated with antibodies. Since the size of many protein molecules, including that of antibodies, is too large to enter the pore system of SBA-16, the amine groups inside the pores are preserved for drug binding. This is proven using a fluorescent protein, fluorescein-isothiocyanate-labeled bovine serum albumin (FITC-BSA), with the unreacted amine groups inside the pores dyed with rhodamine B isothiocyanate (RITC). The resulting nanocomposite material offers a dual-targeting drug delivery mechanism, i.e., magnetic and antibody-targeting, while the functionalization approach is extendable to other applications, e.g., fluorescence-magnetic dual-imaging diagnosis.
Original languageEnglish
Pages (from-to)1599-1609
Number of pages11
JournalAdvanced Functional Materials
Volume20
Issue number10
DOIs
Publication statusPublished - 25 May 2010

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Amines
Nanocomposites
Silicon Dioxide
Antibodies
Bovine Serum Albumin
Fluorescein
Drug delivery
Pharmaceutical Preparations
Proteins
Fluorescence
Nanoparticles
Imaging techniques
Molecules
SBA-16
ferric oxide
isothiocyanic acid
rhodamine isothiocyanate

Cite this

Yiu, Humphrey Hak Ping ; Niu, Hong-jun ; Biermans, Ellen ; van Tendeloo, Gustaaf ; Rosseinsky, Matthew J. / Designed multifunctional nanocomposites for biomedical applications. In: Advanced Functional Materials. 2010 ; Vol. 20, No. 10. pp. 1599-1609.
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Yiu, HHP, Niu, H, Biermans, E, van Tendeloo, G & Rosseinsky, MJ 2010, 'Designed multifunctional nanocomposites for biomedical applications', Advanced Functional Materials, vol. 20, no. 10, pp. 1599-1609. https://doi.org/10.1002/adfm.200902117

Designed multifunctional nanocomposites for biomedical applications. / Yiu, Humphrey Hak Ping; Niu, Hong-jun; Biermans, Ellen; van Tendeloo, Gustaaf; Rosseinsky, Matthew J.

In: Advanced Functional Materials, Vol. 20, No. 10, 25.05.2010, p. 1599-1609.

Research output: Contribution to journalArticle

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