Design of Cellular Porous Biomaterials for Wall Shear Stress Criterion

Yuhang Chen, Shiwei Zhou, Joseph Cadman, Qing Li

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14 Citations (Scopus)

Abstract

The microfluidic environment provided by implanted prostheses has a decisive incluence on the viability, proliferatbion and differentiation of cells. In bone tissue engineering, for instance, experiments have confirmed that a certain level of wall shear stress (WSS) is more advantageous to osteoblastic differentiation. This paper proposesa level-set based topology optimization method to regulate fludic WSS distribution for design of cellular biomaterials. The topological boundary of fluid phase is represented by a level-set medel embedded in a higher-dimentioal scalar function WSS is determined by the computational fluid dynamics analysis in the scale of cellular base cells. To achieve a uniform WSS distribution at the solid-fluid interface, the difference between local and target WSS is taken as the design criterion, which determines the speed of the boundary evolution in the level-set model. the examples demonstrate the effectiveness of the presented method and exhibit a considerable potential in the design optimization and fabrication of new prosthetic celllular materials for bioengineering application. Biotechnol Bioeng. 2010; 107; 737-746. (C) 2010 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)737-746
Number of pages10
JournalBiotechnology and Bioengineering
Volume107
Issue number4
DOIs
Publication statusPublished - 1 Nov 2010

Keywords

  • cellular material
  • level set method
  • wall shear stress
  • solid free form fabrication
  • tissue engineering
  • biofluid
  • COMPUTATIONAL FLUID-DYNAMICS
  • TISSUE ENGINEERING SCAFFOLDS
  • COMPUTER-AIDED-DESIGN
  • LEVEL SET METHOD
  • TOPOLOGY OPTIMIZATION
  • BONE TISSUE
  • STOKES-FLOW
  • FABRICATION
  • PERFUSION
  • ENVIRONMENT

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