Dependence of rat spot14 promoter activity on NF-Y binding to the inverted CCAAT-element at - 100

Karim Roder, Siegmund S. Wolf, Michael Schweizer

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    Electrophoretic mobility shift assay (EMSA) and in vitro transcription/translation show that NF-Y binds to the inverted CCAAT-element in the promoter of the rodent spot14 gene. The NF-Y-binding sequence has been shown to be responsible for basal activity in H4IIE. Given the similar role found for the inverted CCAAT-element in the promoter of the FAS gene, NF-Y may have an important function in the control of lipogenesis.

    Original languageEnglish
    Pages (from-to)848-851
    Number of pages4
    JournalBioscience, Biotechnology and Biochemistry
    Volume64
    Issue number4
    DOIs
    Publication statusPublished - Apr 2000

    Keywords

    • Fatty acid synthase
    • Inverted CCAAT-element
    • NF-Y
    • Spot14 promoter

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